Volume 4, Issue 1 (Winter 2023)
J Vessel Circ 2023, 4(1): 7-14 |
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Ethics code: IR.MUQ.REC.1400.112
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Movahedi Z, Hajian H, Vahedian M, Nouriyani S, Mosleh M, Khoshgoftar M et al . Investigating Hematology and Laboratory Indicators in Children With Suspected and Confirmed COVID-19. J Vessel Circ 2023; 4 (1) :7-14
URL: http://jvessels.muq.ac.ir/article-1-249-en.html
URL: http://jvessels.muq.ac.ir/article-1-249-en.html
Investigating Hematology and Laboratory Indicators in Children With Suspected and Confirmed COVID-19
Zahra Movahedi1 
, Hanieh Hajian1 , Mostafa Vahedian2 , Shima Nouriyani3 , Mahnaz Mosleh4 , Morteza Khoshgoftar1 , Mohamad Amin Mohabatdost * 5
, Hanieh Hajian1 , Mostafa Vahedian2 , Shima Nouriyani3 , Mahnaz Mosleh4 , Morteza Khoshgoftar1 , Mohamad Amin Mohabatdost * 5
1- Department of Pediatrics, School of Medicine, Hazrat-e Fateme Masoume Hospital, Qom University of Medical Sciences, Qom, Iran
2- Department of Family and Community Medicine, Spiritual Health Research Center, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
3- Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
4- Department of Nursing, School of Nursing and Midwifery, Iranshahr University of Medical Sciences, Iranshahr, Iran.
5- Department of Neurosurgery, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
2- Department of Family and Community Medicine, Spiritual Health Research Center, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
3- Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
4- Department of Nursing, School of Nursing and Midwifery, Iranshahr University of Medical Sciences, Iranshahr, Iran.
5- Department of Neurosurgery, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Abstract: (471 Views)
Background and Aim: It is necessary to evaluate the ability to accurately distinguish cases of pneumonia caused by COVID-19 from other cases of pneumonia in blood parameters. Accordingly, this study evaluates the ability of routine laboratory tests to differentiate pneumonia caused by COVID-19 in patients with suspected and confirmed COVID-19.
Materials and Methods: This was a cross-sectional analytical study, and the information of all patients whose COVID-19 tests were positive or were suspected of this disease and met the inclusion criteria was recorded. The laboratory findings were compared between children with suspected and confirmed COVID-19. The data were analyzed using the SPSS software, version 26. The significant level for all tests was considered P<0.05.
Results: The mean age of the patients was 6.16±3.94 years. A total of 56(46.7%) children were boys, and 64(53.3%) were girls. A statistically significant difference was observed between the two groups regarding the number of white blood cells (P=0.021), the number of lymphocytes (P=0.000), erythrocyte sedimentation rate (P=0.021), C-reactive protein (P=0.023), and D-dimer (P=0.012). However, a statistical difference was observed between the two groups regarding the amount of hemoglobin (P=0.413), platelet (P=0.813), blood urea nitrogen (P=0.299), creatinine (P=0.541), sodium (P=0.265), potassium (P=0.973), lactate dehydrogenase (P=0.275), aspartate aminotransferase (P=0.722), alanine aminotransferase (P=0.699), albumin (P=0.341), prothrombin time (P=0.834), partial thromboplastin time (P=0.499), trop (P=0.121), and ferritin (P=0.233).
Conclusion: The result showed that the inflammatory values of erythrocyte sedimentation rate and C-reactive protein are high in children with confirmed COVID-19. Leukopenia and lymphopenia were also observed in these patients. These results in children with the complaint of COVID-19 lead us to the fastest possible diagnosis and early treatment in these patients.
Materials and Methods: This was a cross-sectional analytical study, and the information of all patients whose COVID-19 tests were positive or were suspected of this disease and met the inclusion criteria was recorded. The laboratory findings were compared between children with suspected and confirmed COVID-19. The data were analyzed using the SPSS software, version 26. The significant level for all tests was considered P<0.05.
Results: The mean age of the patients was 6.16±3.94 years. A total of 56(46.7%) children were boys, and 64(53.3%) were girls. A statistically significant difference was observed between the two groups regarding the number of white blood cells (P=0.021), the number of lymphocytes (P=0.000), erythrocyte sedimentation rate (P=0.021), C-reactive protein (P=0.023), and D-dimer (P=0.012). However, a statistical difference was observed between the two groups regarding the amount of hemoglobin (P=0.413), platelet (P=0.813), blood urea nitrogen (P=0.299), creatinine (P=0.541), sodium (P=0.265), potassium (P=0.973), lactate dehydrogenase (P=0.275), aspartate aminotransferase (P=0.722), alanine aminotransferase (P=0.699), albumin (P=0.341), prothrombin time (P=0.834), partial thromboplastin time (P=0.499), trop (P=0.121), and ferritin (P=0.233).
Conclusion: The result showed that the inflammatory values of erythrocyte sedimentation rate and C-reactive protein are high in children with confirmed COVID-19. Leukopenia and lymphopenia were also observed in these patients. These results in children with the complaint of COVID-19 lead us to the fastest possible diagnosis and early treatment in these patients.
Type of Study: Research |
Subject:
hematology
Received: 2023/02/24 | Accepted: 2023/04/29 | Published: 2024/01/2
Received: 2023/02/24 | Accepted: 2023/04/29 | Published: 2024/01/2
References
1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382(8):727-33. [DOI:10.1056/NEJMoa2001017] [PMID] [DOI:10.1056/NEJMoa2001017]
2. Commission WMH. Wuhan Municipal Health Commission's briefing on the pneumonia epidemic situation. 2020; 23108:989.
3. Thompson R. Pandemic potential of 2019-nCoV. Lancet Infect Dis. 2020; 20(3):280. [DOI:10.1016/S1473-3099(20)30068-2] [PMID] [DOI:10.1016/S1473-3099(20)30068-2]
4. Noori E, Vahedian M, Rezvan S, Minaei N, Tabaraii R. The proposed scoring system for hospitalization or discharge of patients with COVID-19. J Emerg Pract Trauma. 2022; 8(1):60-3. [DOI:10.34172/jept.2021.08] [DOI:10.34172/jept.2021.08]
5. Phan LT, Nguyen TV, Luong QC, Nguyen TV, Nguyen HT, Le HQ, et al. Importation and human-to-human transmission of a novel coronavirus in Vietnam. N Engl J Med. 2020; 382(9):872-4. [DOI:10.1056/NEJMc2001272] [PMID] [DOI:10.1056/NEJMc2001272]
6. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of 2019 novel coronavirus infection in China. MedRxiv. 2020. [Link] [DOI:10.1056/NEJMoa2002032]
7. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020; 323(11):1061-9. [DOI:10.1001/jama.2020.1585] [PMID] [DOI:10.1001/jama.2020.1585]
8. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet. 2020; 395(10223):507-13. [DOI:10.1016/S0140-6736(20)30211-7] [PMID] [DOI:10.1016/S0140-6736(20)30211-7]
9. Zhao W, Zhong Z, Xie X, Yu Q, Liu J. Relation between chest CT findings and clinical conditions of coronavirus disease (COVID-19) pneumonia: A multicenter study. AJR Am J Roentgenol. 2020; 214(5):1072-7. [DOI:10.2214/AJR.20.22976] [PMID] [DOI:10.2214/AJR.20.22976]
10. Jin YH, Cai L, Cheng ZS, Cheng H, Deng T, Fan YP, et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Mil Med Res. 2020; 7(1):4. [DOI:10.1186/s40779-020-0233-6] [PMID] [DOI:10.1186/s40779-020-0233-6]
11. Han R, Huang L, Jiang H, Dong J, Peng H, Zhang D. Early clinical and CT manifestations of coronavirus disease 2019 (COVID-19) pneumonia. AJR Am J Roentgenol. 2020; 215(2):338-43. [DOI:10.2214/AJR.20.22961] [PMID] [DOI:10.2214/AJR.20.22961]
12. Huang P, Liu T, Huang L, Liu H, Lei M, Xu W, et al. Use of chest CT in combination with negative RT-PCR assay for the 2019 novel coronavirus but high clinical suspicion. Radiology. 2020; 295(1):22-3. [DOI:10.1148/radiol.2020200330] [PMID] [DOI:10.1148/radiol.2020200330]
13. Rezvan S, Nasiri B, Farahmand H, Ahmadi J, Noori E, Bazmandegan G, et al. Frequency of ABO Blood Groups in patients with covid-19 referred to Ali Ibn Abi Taleb Hospital in Rafsanjan in 2020. J Vessel Circ. 2021; 2(4):171-8. [DOI:10.32598/JVC.2.4.64.7] [DOI:10.32598/JVC.2.4.64.7]
14. Guner Ozenen G, Sahbudak Bal Z, Umit Z, Bilen NM, Yildirim Arslan S, Yurtseven A, et al. Demographic, clinical, and laboratory features of COVID-19 in children: The role of mean platelet volume in predicting hospitalization and severity. J Med Virol. 2021; 93(5):3227-37. [DOI:10.1002/jmv.26902] [PMID] [DOI:10.1002/jmv.26902]
15. Li J, Li S, Cai Y, Liu Q, Li X, Zeng Z, et al. Epidemiological and clinical characteristics of 17 hospitalized patients with 2019 novel coronavirus infections outside Wuhan, China. medRxiv. 2020. [DOI:10.1101/2020.02.11.20022053] [DOI:10.1101/2020.02.11.20022053]
16. Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145(6):e20200702. [DOI:10.1542/peds.2020-0702] [PMID] [DOI:10.1542/peds.2020-0702]
17. Cruz AT, Zeichner SL. COVID-19 in Children: Initial characterization of the pediatric disease. Pediatrics. 2020; 145(6):e20200834. [DOI:10.1542/peds.2020-0834] [PMID] [DOI:10.1542/peds.2020-0834]
18. Ludvigsson JF. Systematic review of COVID-19 in children show milder cases and a better prognosis than adults. Acta Paediatr. 2020; 109(6):1088-95. [DOI:10.1111/apa.15270] [PMID] [DOI:10.1111/apa.15270]
19. Hoang A, Chorath K, Moreira A, Evans M, Burmeister-Morton F, Burmeister F, et al. COVID-19 in 7780 pediatric patients: A systematic review. EClinicalMedicine. 2020; 24:100433. [DOI:10.1016/j.eclinm.2020.100433] [PMID] [DOI:10.1016/j.eclinm.2020.100433]
20. Ding Y, Yan H, Guo W. Clinical characteristics of children with covid-19: A meta-analysis. Front Pediatr. 2020; 8:431. [DOI:10.3389/fped.2020.00431] [PMID] [DOI:10.3389/fped.2020.00431]
21. Henry BM, Benoit SW, de Oliveira MHS, Hsieh WC, Benoit J, Ballout RA, Plebani M, Lippi G. Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): A pooled analysis and review. Clin Biochem. 2020; 81:1-8. [PMID] [DOI:10.1016/j.clinbiochem.2020.05.012]
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