Volume 2, Issue 2 (Spring 2021)
J Vessel Circ 2021, 2(2): 69-76 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Yousefi S, Mohammadi Shahrokhi V, Mehdipour A, Safarian M, Zeinali M, Mirzamohammadi M, et al . Interleukin 4 Is an Important Factor to Overcome Cardiovascular Suspected Patients Independent of CC Chemokine Receptor 5. J Vessel Circ 2021; 2 (2) :69-76
URL: http://jvessels.muq.ac.ir/article-1-75-en.html
URL: http://jvessels.muq.ac.ir/article-1-75-en.html
Soheila Yousefi * 
1, Vahid Mohammadi Shahrokhi2 , Ali Mehdipour2 , Mohammad Safarian2 , Mehdi Zeinali2 , Mojtaba Mirzamohammadi2 , Ali Anbarian2 , Maral Mohammadi Shahrokhi3 , Mohammad Kazemi Arababadi4
1, Vahid Mohammadi Shahrokhi2 , Ali Mehdipour2 , Mohammad Safarian2 , Mehdi Zeinali2 , Mojtaba Mirzamohammadi2 , Ali Anbarian2 , Maral Mohammadi Shahrokhi3 , Mohammad Kazemi Arababadi4
1- Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2- Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
3- Department of Cardiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
4- Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2- Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
3- Department of Cardiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
4- Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Abstract: (1157 Views)
Background and Aim: Interleukin 4 (IL-4) is the main Th2 cytokine, which confers several pleiotropism functions, including induction of fibrosis, and can be induced by CCR5-dependent signaling pathways. Thus, serum levels of IL-4 before and after angiography were explored in this project to clear the roles played by angiography indices, and its related X-ray on the cytokine and CC chemokine receptor 5 (CCR5) delta 32 mutation was explored to find its relation with IL-4 serum levels.
Materials and Methods: In this project, IL-4 serum levels and CCR5 delta 32 mutation were evaluated in the healthy controls, the Acute Coronary Syndrome (ACS) patients without vessel obstruction, those with obstruction of one vessel, and those with more than one vessel obstructions using ELISA and Gap-PCR techniques, respectively. The IL-4 serum levels were explored in the three groups before and after angiography.
Results: The results showed that IL-4 serum levels significantly decreased in the patients without, with one, and with more than one vessel obstructions in comparison to healthy controls. Angiography had no effects on the IL-4 serum levels in all groups when it was compared before and after angiography. IL-4 serum levels had a moderate positive correlation with angiography duration in patients who suffered from severe vessel obstruction. The CCR5 delta 32 mutation was not seen in the participants.
Conclusion: IL-4 can be considered an inhibitory factor for the generation of ACS. Due to the lack of CCR5 delta 32 mutation, it appears that the disease and serum levels of IL-4 were not affected by this mutation.
Materials and Methods: In this project, IL-4 serum levels and CCR5 delta 32 mutation were evaluated in the healthy controls, the Acute Coronary Syndrome (ACS) patients without vessel obstruction, those with obstruction of one vessel, and those with more than one vessel obstructions using ELISA and Gap-PCR techniques, respectively. The IL-4 serum levels were explored in the three groups before and after angiography.
Results: The results showed that IL-4 serum levels significantly decreased in the patients without, with one, and with more than one vessel obstructions in comparison to healthy controls. Angiography had no effects on the IL-4 serum levels in all groups when it was compared before and after angiography. IL-4 serum levels had a moderate positive correlation with angiography duration in patients who suffered from severe vessel obstruction. The CCR5 delta 32 mutation was not seen in the participants.
Conclusion: IL-4 can be considered an inhibitory factor for the generation of ACS. Due to the lack of CCR5 delta 32 mutation, it appears that the disease and serum levels of IL-4 were not affected by this mutation.
Type of Study: Research |
Subject:
cardiovascular diseases
Received: 2021/05/23 | Accepted: 2021/09/22 | Published: 2021/07/1
Received: 2021/05/23 | Accepted: 2021/09/22 | Published: 2021/07/1
References
1. Wang T, Secombes CJ. The evolution of IL-4 and IL-13 and their receptor subunits. Cytokine. 2015; 75(1):8-13. [DOI:10.1016/j.cyto.2015.04.012][PMID] [DOI:10.1016/j.cyto.2015.04.012]
2. Huang XL, Wang YJ, Yan JW, Wan YN, Chen B, Li BZ, et al. Role of anti-inflammatory cytokines IL-4 and IL-13 in systemic sclerosis. Inflamm Res. 2015; 64(3-4):151-9. [DOI:10.1007/s00011-015-0806-0][PMID] [DOI:10.1007/s00011-015-0806-0]
3. Zhao XN, Li YN, Wang YT. Interleukin-4 regulates macrophage polarization via the MAPK signaling pathway to protect against atherosclerosis. Genet Mol Res. 2016; 15(1). [DOI:10.4238/gmr.15017348][PMID] [DOI:10.4238/gmr.15017348]
4. Boss M, Kemmerer M, Brüne B, Namgaladze D. FABP4 inhibition suppresses PPARγ activity and VLDL-induced foam cell formation in IL-4-polarized human macrophages. Atherosclerosis. 2015; 240(2):424-30. [DOI:10.1016/j.atherosclerosis.2015.03.042][PMID] [DOI:10.1016/j.atherosclerosis.2015.03.042]
5. Hong HY, Lee HY, Kwak W, Yoo J, Na MH, So IS, et al. Phage display selection of peptides that home to atherosclerotic plaques: IL-4 receptor as a candidate target in atherosclerosis. J Cell Mol Med. 2008; 12(5B):2003-14. [DOI:10.1111/j.1582-4934.2008.00189.x][PMID] [PMCID] [DOI:10.1111/j.1582-4934.2008.00189.x]
6. Zhao SL, Mo ZH, He HH, Zhao LL, Xie YH. Imbalance of T-helper 1/T-helper 2 cytokines and impaired glucose tolerance among patient with acute coronary syndrome. J Cancer Res Ther. 2018; 14(Supplement):S480-S5. [DOI:10.4103/0973-1482.194346] [PMID] [DOI:10.4103/0973-1482.194346]
7. Mirhafez SR, Zarifian A, Ebrahimi M, Ali RF, Avan A, Tajfard M, et al. [Relationship between serum cytokine and growth factor concentrations and coronary artery disease (Persian)]. Clin Biochem. 2015; 48(9):575-80. [DOI:10.1016/j.clinbiochem.2015.02.002][PMID] [DOI:10.1016/j.clinbiochem.2015.02.002]
8. Jayasuriya H, Herath KB, Ondeyka JG, Polishook JD, Bills GF, Dombrowski AW, et al. Isolation and structure of antagonists of chemokine receptor (CCR5). J Nat Prod. 2004; 67(6):1036-8. [DOI:10.1021/np049974l][PMID] [DOI:10.1021/np049974l]
9. Tarancon-Diez L, De Pablo-Bernal RS, Álvarez-Rios AI, Rosado-Sánchez I, Dominguez-Molina B, Genebat M, et al. CCR5+ CD8 T-cell levels and monocyte activation precede the onset of acute coronary syndrome in HIV-infected patients on antiretroviral therapy. Thromb Haemost. 2017; 117(6):1141-9. [DOI:10.1160/TH16-11-0867][PMID] [DOI:10.1160/TH16-11-0867]
10. Costa C, Traves SL, Tudhope SJ, Fenwick PS, Belchamber KB, Russell RE, et al. Enhanced monocyte migration to CXCR3 and CCR5 chemokines in COPD. Eur Respir J. 2016; 47(4):1093-102. [DOI:10.1183/13993003.01642-2015][PMID] [DOI:10.1183/13993003.01642-2015]
11. Jiang PJ, Zhao AM, Bao SM, Xiao SJ, Xiong M. Expression of chemokine receptors CCR3, CCR5 and CXCR3 on CD4(+) T cells in CBA/JxDBA/2 mouse model, selectively induced by IL-4 and IL-10, regulates the embryo resorption rate. Chin Med J (Engl). 2009; 122(16):1917-21. [PMID]
12. Faulds D, Horuk R. Possible mechanism for the generation of the HIV-1-resistant form of the CCR5 delta32 mutant chemokine receptor. Curr Biol. 1997; 7(9):R529-30. [DOI:10.1016/s0960-9822(06)00272-7][PMID] [DOI:10.1016/S0960-9822(06)00272-7]
13. Eckert J, Schmidt M, Magedanz A, Voigtländer T, Schmermund A. Coronary CT angiography in managing atherosclerosis. Int J Mol Sci. 2015; 16(2):3740-56. [DOI:10.3390/ijms16023740][PMID] [PMCID] [DOI:10.3390/ijms16023740]
14. Liu T, Pei H, Xu D, Zhang Y, Wan J, Wu X, et al. GANRA-5 protects mice from X-ray irradiation-induced dysfunction of the immune system. Free Radic Res. 2014; 48(8):875-82. [DOI:10.3109/10715762.2014.919389][PMID] [DOI:10.3109/10715762.2014.919389]
15. Yoshino H, Kashiwakura I. Involvement of reactive oxygen species in ionizing radiation-induced upregulation of cell surface Toll-like receptor 2 and 4 expression in human monocytic cells. J Radiat Res. 2017; 58(5):626-35. [DOI:10.1093/jrr/rrx011] [PMID] [PMCID] [DOI:10.1093/jrr/rrx011]
16. Csiszar A, Ungvari Z. Synergistic effects of vascular IL-17 and TNFalpha may promote coronary artery disease. Med Hypotheses. 2004; 63(4):696-8. [DOI:10.1016/j.mehy.2004.03.009][PMID] [DOI:10.1016/j.mehy.2004.03.009]
17. Hilderman M, Qureshi AR, Abtahi F, Witt N, Jägren C, Olbers J, et al. The cholinergic anti-inflammatory pathway in resistant hypertension treated with renal denervation. Mol Med. 2019; 25(1):39. [DOI:10.1186/s10020-019-0097-y][PMID][PMCID] [DOI:10.1186/s10020-019-0097-y]
18. Szkodzinski J, Hudzik B, Osuch M, Romanowski W, Szygula-Jurkiewicz B, Polonski L, et al. Serum concentrations of interleukin-4 and interferon-gamma in relation to severe left ventricular dysfunction in patients with acute myocardial infarction undergoing percutaneous coronary intervention. Heart Vessels. 2011; 26(4):399-407. [DOI:10.1007/s00380-010-0076-2] [PMID] [DOI:10.1007/s00380-010-0076-2]
19. Rodríguez-Rabassa M, López P, Rodríguez-Santiago RE, Cases A, Felici M, Sánchez R, et al. Cigarette smoking modulation of saliva microbial composition and cytokine levels. Int J Environ Res Public Health. 2018; 15(11):2479. [DOI:10.3390/ijerph15112479] [PMID] [PMCID] [DOI:10.3390/ijerph15112479]
20. Mitra A, Vishweswaraiah S, Thimraj TA, Maheswarappa M, Krishnarao CS, Sundararaja Lokesh K, et al. Association of elevated serum GM-CSF, IFN-γ, IL-4, and TNF-α concentration with tobacco smoke induced chronic obstructive pulmonary disease in a south indian population. Int J Inflam. 2018; 2018:2027856. [DOI:10.1155/2018/2027856] [PMID] [PMCID] [DOI:10.1155/2018/2027856]
21. Miranda TS, Heluy SL, Cruz DF, da Silva HD, Feres M, Figueiredo LC, et al. The ratios of pro-inflammatory to anti-inflammatory cytokines in the serum of chronic periodontitis patients with and without type 2 diabetes and/or smoking habit. Clin Oral Invest. 2019; 23(2):641-50. [DOI:10.1007/s00784-018-2471-5] [DOI:10.1007/s00784-018-2471-5]
22. Ayatollahi-Mousavi SA, Asadikaram G, Nakhaee N, Izadi A, Keikha N. [The effects of opium addiction on the immune system function in patients with fungal infection (Persian)]. Addict Health. 2016; 8(4):218-26. [PMID] [PMCID]
23. Ghazavi A, Solhi H, Moazzeni SM, Rafiei M, Mosayebi G. [Cytokine profiles in long-term smokers of opium (Taryak) (Persian)]. J Addict Med. 2013; 7(3):200-3. [DOI:10.1097/ADM.0b013e31828baede][PMID] [DOI:10.1097/ADM.0b013e31828baede]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Owned by Qom University of Medical Sciences
Published by Qom University of Medical Sciences Press
eISSN: 2717-0357
Email: jvessels[at]muq.ac.ir
j.vessels.circul[at]gmail.com
