Volume 1, Issue 1 (Winter 2020)
J Vessel Circ 2020, 1(1): 8-12 |
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Vahedian M, Mohammadi Berenjegani A, Yousefi M, Hassanvand-Amouzadeh M, Rezvan S, Noori E, et al . Frequency of Long QT Syndrome in Seizure Patients with no Underlying Cause. J Vessel Circ 2020; 1 (1) :8-12
URL: http://jvessels.muq.ac.ir/article-1-31-en.html
URL: http://jvessels.muq.ac.ir/article-1-31-en.html
Mostafa Vahedian1 
, Abutaleb Mohammadi Berenjegani1 , Maryam Yousefi2 , Masoud Hassanvand-Amouzadeh3 , Sajad Rezvan4 , Enayatollah Noori5 , Mohammad Hosein Arjmandnia * 3, Atefeh Mirzaie5
, Abutaleb Mohammadi Berenjegani1 , Maryam Yousefi2 , Masoud Hassanvand-Amouzadeh3 , Sajad Rezvan4 , Enayatollah Noori5 , Mohammad Hosein Arjmandnia * 3, Atefeh Mirzaie5
1- School of Medicine, Qom University of Medical Sciences
2- Qom University of Medical Sciences
3- Department of Pediatrics, School of Medicine, Qom University of Medical Sciences
4- Rafsanjan University of Medical Sciences
5- Student Research Committee Qom University of Medical Sciences
2- Qom University of Medical Sciences
3- Department of Pediatrics, School of Medicine, Qom University of Medical Sciences
4- Rafsanjan University of Medical Sciences
5- Student Research Committee Qom University of Medical Sciences
Abstract: (2026 Views)
Background and Aims: There are contradictory data regarding the changes of corrected QT interval (QTc) in seizure. Regarding this, the present study aimed to evaluate the prevalence of long QT syndrome (LQTS) in seizure patients without underlying cause in Hazrat-e Masoumeh Hospital, Qom, Iran.
Materials and Methods: The present cross-sectional study was conducted on seizure patients without any underlying causes. The data were collected using a questionnaire covering such variables as age, gender, and history of seizure and syncope. Electrocardiogram (ECG) was obtained from the patients in the first 2 h after the occurrence of seizure. Moreover, the distance from the beginning of the Q wave to the end of the T wave in the lead limb II was measured by the researcher. Finally, the collected data were analyzed in SPSS software (version 22).
Results: The participants consisted of 67 males (55.8%) and 53 females (44.2%) with the mean age of 6.7±2.1 years. Long QT was observed in five patients. The gender of the participants had no significant relationship with the type of seizure and family history of syncope, sudden death, heart disease, and seizure (P≥0.05). The mean QT intervals in the males and females were 0.40±0.24 and 0.40±0.23 sec, respectively. Therefore, no significant difference was observed between the male and female patients in this regard (P≥0.05).
Conclusion: Based on the results, LQTS in seizure patients without underlying causes was found in only five patients. However, in special cases, such as a family history of QTc disorders, history of suspected faint, and resistant or status epilepticus, the implementation of ECGs can be helpful for children.
Materials and Methods: The present cross-sectional study was conducted on seizure patients without any underlying causes. The data were collected using a questionnaire covering such variables as age, gender, and history of seizure and syncope. Electrocardiogram (ECG) was obtained from the patients in the first 2 h after the occurrence of seizure. Moreover, the distance from the beginning of the Q wave to the end of the T wave in the lead limb II was measured by the researcher. Finally, the collected data were analyzed in SPSS software (version 22).
Results: The participants consisted of 67 males (55.8%) and 53 females (44.2%) with the mean age of 6.7±2.1 years. Long QT was observed in five patients. The gender of the participants had no significant relationship with the type of seizure and family history of syncope, sudden death, heart disease, and seizure (P≥0.05). The mean QT intervals in the males and females were 0.40±0.24 and 0.40±0.23 sec, respectively. Therefore, no significant difference was observed between the male and female patients in this regard (P≥0.05).
Conclusion: Based on the results, LQTS in seizure patients without underlying causes was found in only five patients. However, in special cases, such as a family history of QTc disorders, history of suspected faint, and resistant or status epilepticus, the implementation of ECGs can be helpful for children.
Type of Study: Research |
Subject:
stroke
Received: 2019/12/3 | Accepted: 2020/01/1 | Published: 2020/01/30
Received: 2019/12/3 | Accepted: 2020/01/1 | Published: 2020/01/30
References
1. 1. Lowenstein DH. Seizurse and epilepsy. In: Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison's principles of internal medicine. New York: McGraw-Hill Companies; 2001. P. 2354-5. Link
2. Greenberg DA, Aminoff MJ, Simon RP. Clinical neurology. New York: McGraw-Hill; 2018. P. 155-6. Link
3. Siroha K, Rasool W, Verma A, Jaiswal S. Unusual case of seizures due to long QT syndrome-a case report. Indian J Case Report 2018;4(1):59-60. Link [DOI:10.32677/IJCR.2018.v04.i01.020]
4. Galtrey CM, Levee V, Arevalo J, Wren D. Long QT syndrome masquerading as epilepsy. Pract Neurol 2019;19(1):56-61. PMID: 30323052 [DOI:10.1136/practneurol-2018-001959]
5. Steinberg C. Diagnosis and clinical management of long-QT syndrome. Curr Opin Cardiol 2018;33(1):31-41. PMID: 28984650 [DOI:10.1097/HCO.0000000000000465]
6. Arnestad M, Crotti L, Rognum TO, Insolia R, Pedrazzini M, Ferrandi C, et al. Prevalence of long-QT syndrome gene variants in sudden infant death syndrome. Circulation 2007;115(3):361-7. PMID: 17210839 [DOI:10.1161/CIRCULATIONAHA.106.658021]
7. Suzuki Y, Miyajima M, Ohta K, Yoshida N, Omoya R, Fujiwara M, et al. Is prolongation of corrected QT interval associated with seizures induced by electroconvulsive therapy reduced by atropine sulfate? Pacing Clin Electrophysiol 2017;40(11):1246-53. PMID: 28862317 [DOI:10.1111/pace.13188]
8. Moss AJ. Long QT syndrome. JAMA 2003;289(16):2041-4. PMID: 12709446 [DOI:10.1001/jama.289.16.2041]
9. Cusimano F, Martines E, Rizzo C. The Jervell and Lange-Nielsen syndrome. Int J Pediatr Otorhinolaryngol 1991;22(1):49-58. PMID: 1917338 [DOI:10.1016/0165-5876(91)90096-T]
10. Tabiban S, Ëbadi K, Golshani S, Amini SM. Long-QT syndrome: a treated and saved case from sudden death. J Mazandaran Univ Med Sci 2010;20(78):77-81. Link
11. Sadrnia S, Yousefi P, Jalali L. Correlation between seizure in children and long QT interval. ARYA Atheroscler 2013;9(1):7-10. PMID: 23696753
12. Akhtar MJ. All seizures are not epilepsy: many have a cardiovascular cause. J Pak Med Assoc 2002;52(3):116-9. PMID: 12071066
13. Burghaus L, Liu W, Eggers C, Müller-Ehmsen J, Fink GR. Mistaking a long QT syndrome for epilepsy: does every seizure call for an ECG? Fortschr Neurol Psychiatr 2010;78(7):419-24. PMID: 20533164 [DOI:10.1055/s-0029-1245443]
14. Raghavan SS. Pediatric long QT syndrome. The Heart Medscape. Available at: URL: https://emedicine.medscape.com/article/891571-overview; 2014. Link
15. Eriksson K, Koivikko M. Prevalence, classification, and severity of epilepsy and epileptic syndromes in children. Epilepsia 1997;38(12):1275-82. PMID: 9578522 [DOI:10.1111/j.1528-1157.1997.tb00064.x]
16. Garson A Jr, Dick M 2nd, Fournier A, Gillette PC, Hamilton R, Kugler JD, et al. The long QT syndrome in children. An international study of 287 patients. Circulation 1993;87(6):1866-72. PMID: 8099317 [DOI:10.1161/01.CIR.87.6.1866]
17. Lim SM, Pak HN, Lee MH, Kim SS, Joung B. Fever-induced QTc prolongation and ventricular fibrillation in a healthy young man. Yonsei Med J 2011;52(6):1025-7. PMID: 22028170 [DOI:10.3349/ymj.2011.52.6.1025]
18. Amin AS, Herfst LJ, Delisle BP, Klemens CA, Rook MB, Bezzina CR, et al. Fever-induced QTc prolongation and ventricular arrhythmias in individuals with type 2 congenital long QT syndrome. J Clin Invest 2008;118(7):2552-61. PMID: 18551196 [DOI:10.1172/JCI35337]
19. Brotherstone R, Blackhall B, McLellan A. Lengthening of corrected QT during epileptic seizures. Epilepsia 2010;51(2):221-32. PMID: 19732135 [DOI:10.1111/j.1528-1167.2009.02281.x]
20. Akalin F, Tirtir A, Yilmaz Y. Increased QT dispersion in epileptic children. Acta Paediatr 2003;92(8):916-20. PMID: 12948066 [DOI:10.1111/j.1651-2227.2003.tb00624.x]
21. Dogan EA, Dogan U, Yildiz GU, Akilli H, Genc E, Genc BO, et al. Evaluation of cardiac repolarization indices in well-controlled partial epilepsy: 12-Lead ECG findings. Epilepsy Res 2010;90(1-2):157-63. PMID: 20488665 [DOI:10.1016/j.eplepsyres.2010.04.008]
22. Teh HS, Tan HJ, Loo CY, Raymond AA. Short QTc in epilepsy patients without cardiac symptoms. Med J Malaysia 2007;62(2):104-8. PMID: 18705439
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