Volume 4, Issue 3 (Summer 2023)
J Vessel Circ 2023, 4(3): 133-138 |
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Ethics code: IR.MUQ.REC.1400.087
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Razavi M R, Sharifi A, Akhavan Sepahi M, Afshari M H, Riahi M, Aghaali M et al . Thyroid Hormone Profile in Pediatrics With Nephrotic Syndrome Compared to Healthy Childre. J Vessel Circ 2023; 4 (3) :133-138
URL: http://jvessels.muq.ac.ir/article-1-273-en.html
URL: http://jvessels.muq.ac.ir/article-1-273-en.html
Mohammad Reza Razavi1 
, Alireza Sharifi2 , Mohsen Akhavan Sepahi1 , Mohammad Hossein Afshari3 , Mobina Riahi4 , Mohammad Aghaali5 , Sahar Ghaedsharaf6
, Alireza Sharifi2 , Mohsen Akhavan Sepahi1 , Mohammad Hossein Afshari3 , Mobina Riahi4 , Mohammad Aghaali5 , Sahar Ghaedsharaf6
1- Department of Pediatrics, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
2- Department of Otolaryngology-Head and Neck Surgery, Amir A’lam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
3- Student Research Committee, Qom University of Medical Sciences, Qom, Iran.
4- Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
5- Department of Oral and Maxillofacial Radiology, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
6- Department of Oral and Maxillofacial Radiology, School of Dentistry, Shahid Beheshti University, Tehran, Iran.
2- Department of Otolaryngology-Head and Neck Surgery, Amir A’lam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
3- Student Research Committee, Qom University of Medical Sciences, Qom, Iran.
4- Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
5- Department of Oral and Maxillofacial Radiology, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
6- Department of Oral and Maxillofacial Radiology, School of Dentistry, Shahid Beheshti University, Tehran, Iran.
Abstract: (466 Views)
Background and Aim: Nephrotic syndrome (NS) is one of the most common kidney diseases in pediatrics. It impacts thyroid hormones due to the urinary loss of hormone-binding proteins such as transthyretin, thyroxine-binding globulin (TBG), and albumin.
Objectives: This study aimed to compare the profile of thyroid hormones between children with a definite diagnosis of NS and healthy children.
Materials and Methods: This retrospective case-control study was performed in a pediatric university hospital between January 2011 and December 2021. The case group consisted of all children with a definite diagnosis of NS who were referred to our hospital, while healthy children who visited the hospital for routine checkups were randomly enrolled in the control group. All variables were compared between the case and control groups.
Results: The median age of children was 5.91±4.14 and 6.07±3.70 years in the control and case groups, respectively. Thyroid stimulator hormone (TSH) and thyroxin-4 (T4) levels were significantly higher and lower in the case group than in the control group, respectively (P<0.05). There was no significant difference between the case and control groups in free T4 levels (1.30±1.95 and 1.12±0.24 ng/dL, respectively; P=0.558).
Conclusion: Subclinical hypothyroidism is more common in children with NS. This may be due to albuminuria and the loss of TBG during active proteinuria stages.
Objectives: This study aimed to compare the profile of thyroid hormones between children with a definite diagnosis of NS and healthy children.
Materials and Methods: This retrospective case-control study was performed in a pediatric university hospital between January 2011 and December 2021. The case group consisted of all children with a definite diagnosis of NS who were referred to our hospital, while healthy children who visited the hospital for routine checkups were randomly enrolled in the control group. All variables were compared between the case and control groups.
Results: The median age of children was 5.91±4.14 and 6.07±3.70 years in the control and case groups, respectively. Thyroid stimulator hormone (TSH) and thyroxin-4 (T4) levels were significantly higher and lower in the case group than in the control group, respectively (P<0.05). There was no significant difference between the case and control groups in free T4 levels (1.30±1.95 and 1.12±0.24 ng/dL, respectively; P=0.558).
Conclusion: Subclinical hypothyroidism is more common in children with NS. This may be due to albuminuria and the loss of TBG during active proteinuria stages.
Type of Study: Research |
Subject:
vascular nephrology
Received: 2024/01/19 | Accepted: 2024/03/11 | Published: 2024/02/29
Received: 2024/01/19 | Accepted: 2024/03/11 | Published: 2024/02/29
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