Volume 4, Issue 2 (Spring 2023)                   J Vessel Circ 2023, 4(2): 53-58 | Back to browse issues page

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Adeli S H, Javadi S, Aghaali M, Parham M. The Relationship Between Diabetic Peripheral Neuropathy and Pulmonary Function Tests. J Vessel Circ 2023; 4 (2) :53-58
URL: http://jvessels.muq.ac.ir/article-1-268-en.html
The Relationship Between Diabetic Peripheral Neuropathy and Pulmonary Function Tests
Seyed Hasan Adeli1 , Saeedeh Javadi2 , Mohammad Aghaali3 , Mahmoud Parham * 4
1- Department of Internal Medicine, Spiritual Health Research Center, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
2- Student Research Committee, Qom University of Medical Sciences, Qom, Iran.
3- Department of Family and Community Medicine, Neuroscience Research Center, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
4- Department of Internal Medicine, Gastroenterology and Hepatology Diseases Research Center, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
Abstract:   (392 Views)
Background and Aim: Diabetes mellitus (DM) is a systemic disease with complications in the cardiovascular system, nerves, eyes, and kidneys. The potential targeting of the lung as an organ in diabetes is suggested by the rich pulmonary microvascular circulation and ample connective tissue present. This study aims to assess the relationship between pulmonary function tests and diabetic peripheral neuropathy in patients with type 2 DM.
Materials and Methods: One hundred patients were included in the study. Michigan neuropathy screening instrument (MNSI) was used to evaluate diabetic peripheral neuropathy in all patients. Based on the results of the MNSI, patients were divided into two groups, 50 diabetic subjects without neuropathy and 50 subjects with neuropathy. Also, a flow-sensitive spirometer was used to evaluate the pulmonary function test (PFT) for all subjects. All the pulmonary function parameters were measured as a percentage of predicted value. In addition, according to hemoglobin A1c (HbA1c) level, patients were divided to three groups (group 1≤7%, group 2=7%-9%, group 3≥9%).
Results: No significant difference was observed between the two groups with and without diabetic neuropathy in terms of PFTs, but in subjects with diabetic peripheral neuropathy, a significant reduction of forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) was observed in group 3 (HbA1c >9) compared to groups 1 (HbA1c <7).
Conclusion: This study does not show a significant reduction in pulmonary function in patients with type-2 DM with neuropathy compared to those without neuropathy. However, a significant difference was observed in FVC, FEV1, and forced expiratory flow (FEF)25-75 based on HBA1C level in subjects with neuropathy.
Keywords: Diabetic peripheral neuropathy, Pulmonary function, Type 2 diabetes
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Type of Study: Research | Subject: vascular pulmonology
Received: 2023/11/24 | Accepted: 2023/12/27 | Published: 2024/02/29
References
1. Fauci AS, Longo D, Kasper DL, Jameson JL, Loscalzo J, Hauser S. Harrison's principles of internal medicine. Twenty-first edition. New York: McGraw Hill Medical; 2022. [Link]
2. Marvisi M, Bartolini L, del Borrello P, Brianti M, Marani G, Guariglia A, et al. Pulmonary function in non-insulin-dependent diabetes mellitus. Respiration. 2001; 68(3):268-72. [DOI:10.1159/000050509] [PMID] [DOI:10.1159/000050509]
3. Kahnert K, Lucke T, Biertz F, Lechner A, Watz H, Alter P, et al. Transfer factor for carbon monoxide in patients with COPD and diabetes: Results from the German COSYCONET cohort. Respir Res. 2017; 18(1):14. [DOI:10.1186/s12931-016-0499-0] [PMID] [PMCID] [DOI:10.1186/s12931-016-0499-0]
4. Wimmer RA, Leopoldi A, Aichinger M, Wick N, Hantusch B, Novatchkova M, et al. Human blood vessel organoids as a model of diabetic vasculopathy. Nature. 2019; 565(7740):505-10. [DOI:10.1038/s41586-018-0858-8] [PMID] [PMCID] [DOI:10.1038/s41586-018-0858-8]
5. Fida A, Javed MS, Rasool F. Diabetic pneumopathy: A latest finding. J Pak Med Assoc. 2023; 73(11):2304. [DOI:10.47391/JPMA.10133] [PMID] [DOI:10.47391/JPMA.10133]
6. Li Y, Liu Y, Liu S, Gao M, Wang W, Chen K, et al. Diabetic vascular diseases: Molecular mechanisms and therapeutic strategies. Signal Transduct Target Ther. 2023; 8(1):152. [DOI:10.1038/s41392-023-01400-z] [PMID] [PMCID] [DOI:10.1038/s41392-023-01400-z]
7. Gul CB, Oz Gul O, Cander S, Eroglu A, Hartavi M, Keni N, et al. Relationship between glycemic control, microalbuminuria and cognitive functions in elderly type 2 diabetic patients. Ren Fail. 2014; 36(8):1258-62. [DOI:10.3109/0886022X.2014.938576] [PMID] [DOI:10.3109/0886022X.2014.938576]
8. Klein OL, Krishnan JA, Glick S, Smith LJ. Systematic review of the association between lung function and type 2 diabetes mellitus. Diabet Med. 2010; 27(9):977-87. [DOI:10.1111/j.1464-5491.2010.03073.x] [PMID] [DOI:10.1111/j.1464-5491.2010.03073.x]
9. Hsia CC, Raskin P. Lung involvement in diabetes: Does it matter? Diabetes Care. 2008; 31(4):828-9. [DOI:10.2337/dc08-0103] [PMID] [DOI:10.2337/dc08-0103]
10. Feldman EL, Stevens MJ, Thomas PK, Brown MB, Canal N, Greene DA. A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. Diabetes Care. 1994; 17(11):1281-9. [DOI:10.2337/diacare.17.11.1281] [PMID] [DOI:10.2337/diacare.17.11.1281]
11. Graham BL, Steenbruggen I, Miller MR, Barjaktarevic IZ, Cooper BG, Hall GL, et al. Standardization of spirometry 2019 update. An official american thoracic society and european respiratory society technical statement. Am J Respir Crit Care Med. 2019; 200(8):e70-88. [DOI:10.1164/rccm.201908-1590ST] [PMID] [PMCID] [DOI:10.1164/rccm.201908-1590ST]
12. van den Borst B, Gosker HR, Zeegers MP, Schols AM. Pulmonary function in diabetes: A metaanalysis. Chest. 2010; 138(2):393-406. [DOI:10.1378/chest.09-2622] [PMID] [DOI:10.1378/chest.09-2622]
13. Bai L, Zhang L, Pan T, Wang W, Wang D, Turner C, et al. Idiopathic pulmonary fibrosis and diabetes mellitus: A meta-analysis and systematic review. Respir Res. 2021; 22(1):175. [DOI:10.1186/s12931-021-01760-6] [PMID] [PMCID] [DOI:10.1186/s12931-021-01760-6]
14. Ali MO. Pulmonary complications in diabetes mellitus. Mymensingh Med J. 2014; 23(3):603-5. [PMID]
15. Vojtková J, Ciljaková M, Michnová Z, Turčan T. Chronic complications of diabetes mellitus related to the respiratory system. Pediatr Endocrinol Diabetes Metab. 2012; 18(3):112-5. [PMID]
16. Scaramuzza AE, Morelli M, Rizzi M, Borgonovo S, De Palma A, Mameli C, et al. Impaired diffusing capacity for carbon monoxide in children with type 1 diabetes: Is this the first sign of long-term complications? Acta Diabetol. 2012;49(2):159-64. [DOI:10.1007/s00592-011-0353-2] [DOI:10.1007/s00592-011-0353-2]
17. Kolahian S, Leiss V, Nürnberg B. Diabetic lung disease: Fact or fiction? Rev Endocr Metab Disord. 2019 Sep;20(3):303-19. [DOI:10.1007/s11154-019-09516-w] [PMID] [PMCID] [DOI:10.1007/s11154-019-09516-w]
18. Shafiee G, Khamseh ME, Rezaei N, Aghili R, Malek M. Alteration of pulmonary function in diabetic nephropathy. J Diabetes Metab Disord. 2013; 12(1):15. [DOI:10.1186/2251-6581-12-15] [PMID] [PMCID] [DOI:10.1186/2251-6581-12-15]
19. Girach A, Manner D, Porta M. Diabetic microvascular complications: Can patients at risk be identified? A review. Int J Clin Pract. 2006; 60(11):1471-83. [DOI:10.1111/j.1742-1241.2006.01175.x] [PMID] [DOI:10.1111/j.1742-1241.2006.01175.x]
20. Agarwal AS, Fuladi AB, Mishra G, Tayade BO. Spirometry and diffusion studies in patients with type-2 diabetes mellitus and their association with microvascular complications. Indian J Chest Dis Allied Sci. 2010; 52(4):213-6. [DOI:10.5005/ijcdas-52-4-213] [PMID] [DOI:10.5005/ijcdas-52-4-213]
21. Sinha S, Guleria R, Misra A, Pandey RM, Yadav R, Tiwari S. Pulmonary functions in patients with type 2 diabetes mellitus & correlation with anthropometry & microvascular complications. Indian J Med Res. 2004; 119(2):66-71. [PMID]
22. Chance WW, Rhee C, Yilmaz C, Dane DM, Pruneda ML, Raskin P, et al. Diminished alveolar microvascular reserves in type 2 diabetes reflect systemic microangiopathy. Diabetes Care. 2008; 31(8):1596-601. [DOI:10.2337/dc07-2323] [PMID] [PMCID] [DOI:10.2337/dc07-2323]
23. Rajput S, Parashar R, Sharma JP, Raghuwanshi P, Pakhare AP, Joshi R, et al. Assessment of pulmonary functions and dysfunctions in type II diabetes mellitus: A comparative cross-sectional study. Cureus. 2023; 15(2):e35081. [DOI:10.7759/cureus.35081] [DOI:10.7759/cureus.35081]
24. Shah SH, Sonawane P, Nahar P, Vaidya S, Salvi S. Pulmonary function tests in type 2 diabetes mellitus and their association with glycemic control and duration of the disease. Lung India. 2013; 30(2):108-12. [DOI:10.4103/0970-2113.110417] [PMID] [PMCID] [DOI:10.4103/0970-2113.110417]
25. Panpalia NG, Kulkarni S, Aundhkar SC, Agrawal S, Lakhotia A, Choraria K. To study the effects of diabetes mellitus on pulmonary function tests. Int J Health Sci Res. 2014; 4(5):108-19. [Link]
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