Volume 4, Issue 2 (Spring 2023)
J Vessel Circ 2023, 4(2): 67-74 |
Back to browse issues page
Ethics code: IR.IUMS.FMD.REC.1400.006
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Yaghoobi N, Hekmat S, Malek H, Hedayati R, Salimian S. Epidemiologic Evaluation of the Blunted Heart Rate Response in Chronic Kidney Disease and Its Associated Factors. J Vessel Circ 2023; 4 (2) :67-74
URL: http://jvessels.muq.ac.ir/article-1-263-en.html
URL: http://jvessels.muq.ac.ir/article-1-263-en.html
1- Department of Nuclear Medicine, Rajaie Cardiovascular, Medical and Research Center, Rajaie Cardiovascular, Medical and Research Institute, Tehran, Iran.
2- Department of Nuclear Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Nuclear Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Nuclear Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Nuclear Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract: (527 Views)
Background and Aim: Previous studies on heart response rate (HRR) were conducted in diabetic patients. This study aims to evaluate HRR in end-stage renal disease (ESRD) patients and its correlation with myocardial perfusion imaging (MPI) findings and patients’ prognosis.
Materials and Methods: The present study was conducted on patients with chronic kidney disease (CKD) who visited Shahid Hasheminejad Hospital between October 1, 2011, and September 30, 2019. Before the stress test, the patient was asked to rest in a supine position for 3 minutes while an electrocardiogram, blood pressure, and heart rate were recorded. Dipyridamole was then administered as an infusion with a dose of approximately 0.56 mg/kg of the patient’s monitoring of the electrocardiogram. The patient’s heart rate was recorded at 2-minute intervals after the start of the dipyridamole injection. Three minutes after the completion of the dipyridamole injection, radiopharmaceutical was injected. Finally, the findings of the myocardial perfusion scan were analyzed.
Results: The summed stress score (SSS), and summed rest score (SRS) had a significant relationship with the female gender and ejection fraction (EF) with the male gender (P<0.05). These results were not significantly related to patients’ age and disease history (P>0.05). No significant difference was observed in the incidence of blunted HRR in patients with cardiac events by age, gender, and renal disease condition (P>0.05).
Conclusion: The frequency of blunted HRR in patients with CKD based on various variables was determined for the first time in the country in the present study, which can be an introduction for future research.
Materials and Methods: The present study was conducted on patients with chronic kidney disease (CKD) who visited Shahid Hasheminejad Hospital between October 1, 2011, and September 30, 2019. Before the stress test, the patient was asked to rest in a supine position for 3 minutes while an electrocardiogram, blood pressure, and heart rate were recorded. Dipyridamole was then administered as an infusion with a dose of approximately 0.56 mg/kg of the patient’s monitoring of the electrocardiogram. The patient’s heart rate was recorded at 2-minute intervals after the start of the dipyridamole injection. Three minutes after the completion of the dipyridamole injection, radiopharmaceutical was injected. Finally, the findings of the myocardial perfusion scan were analyzed.
Results: The summed stress score (SSS), and summed rest score (SRS) had a significant relationship with the female gender and ejection fraction (EF) with the male gender (P<0.05). These results were not significantly related to patients’ age and disease history (P>0.05). No significant difference was observed in the incidence of blunted HRR in patients with cardiac events by age, gender, and renal disease condition (P>0.05).
Conclusion: The frequency of blunted HRR in patients with CKD based on various variables was determined for the first time in the country in the present study, which can be an introduction for future research.
Type of Study: Research |
Subject:
interventional vascular radiology
Received: 2023/09/24 | Accepted: 2023/10/17 | Published: 2024/02/29
Received: 2023/09/24 | Accepted: 2023/10/17 | Published: 2024/02/29
References
1. Ix JH, Sharma K. Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: The roles of fetuin-A, adiponectin, and AMPK. J Am Soc Nephrol. 2010; 21(3):406-12. [DOI:10.1681/ASN.2009080820] [PMID] [PMCID] [DOI:10.1681/ASN.2009080820]
2. Meguid El Nahas A, Bello AK. Chronic kidney disease: The global challenge. Lancet. 2005; 365(9456):331-40. [DOI:10.1016/S0140-6736(05)17789-7] [PMID] [DOI:10.1016/S0140-6736(05)17789-7]
3. Targher G, Mantovani A, Pichiri I, Mingolla L, Cavalieri V, Mantovani W, et al. Nonalcoholic fatty liver disease is independently associated with an increased incidence of chronic kidney disease in patients with type 1 diabetes. Diabetes Care. 2014; 37(6):1729-36. [DOI:10.2337/dc13-2704] [PMID] [DOI:10.2337/dc13-2704]
4. Bonora E, Targher G. Increased risk of cardiovascular disease and chronic kidney disease in NAFLD. Nat Rev Gastroenterol Hepatol. 2012; 9(7):372-81. [DOI:10.1038/nrgastro.2012.79] [PMID] [DOI:10.1038/nrgastro.2012.79]
5. Kroneberger C, Enzweiler CN, Schmidt-Lucke A, Rückert RI, Teichgräber U, Franiel T. Contrast-induced nephropathy in patients with chronic kidney disease and peripheral arterial disease. Acta Radiol Open. 2015; 4(6):2058460115583034.[DOI:10.1177/2058460115583034] [PMID] [PMCID] [DOI:10.1177/2058460115583034]
6. Ell PJ, Gambhir SS. Nuclear medicine in clinical diagnosis and treatment. J Nucl Med. 2005; 46(8):1402-3. [Link]
7. Ziessman HA, O'Malley JP, Thrall JH. Nuclear medicine: The requisites e-book. Edinburgh: Elsevier Health Sciences; 2013. [Link]
8. Hannoush H, Shaar K, Alam S, Nasrallah A, Sawaya J, Dakik HA. Analysis of referral patterns, predictive accuracy, and impact on patient management of myocardial perfusion imaging in a new nuclear cardiology laboratory. J Nucl Cardiol. 2003; 10(2):148-53. [DOI:10.1067/mnc.2003.397] [PMID] [DOI:10.1067/mnc.2003.397]
9. Kumar R, Patel CD, Marwah A, Gupta R, Sharma S, Malhotra A. Detection of coronary artery disease by stress thallium scintigraphy in diabetic patients. Nucl Med Commun. 2001; 22(3):287-9. [DOI:10.1097/00006231-200103000-00005] [PMID] [DOI:10.1097/00006231-200103000-00005]
10. Kamínek M, Myslivecek M, Skvarilová M, Weinbergová O, Metelka R, Husák V, et al. [Prognostic significance of stress tomographic scintigraphy of myocardial perfusion in diabetic patients (Czech)]. Vnitr Lek. 2001 Nov;47(11):739-43. [PMID]
11. Giri S, Shaw LJ, Murthy DR, Travin MI, Miller DD, Hachamovitch R, et al. Impact of diabetes on the risk stratification using stress single-photon emission computed tomography myocardial perfusion imaging in patients with symptoms suggestive of coronary artery disease. Circulation. 2002; 105(1):32-40. [DOI:10.1161/hc5001.100528] [PMID] [DOI:10.1161/hc5001.100528]
12. De Lima JJ, Sabbaga E, Vieira ML, de Paula FJ, Ianhez LE, Krieger EM, et al. Coronary angiography is the best predictor of events in renal transplant candidates compared with noninvasive testing. Hypertension. 2003; 42(3):263-8. [DOI:10.1161/01.HYP.0000087889.60760.87] [PMID] [DOI:10.1161/01.HYP.0000087889.60760.87]
13. Kamal A, Hassan E, Azab S, Abdelaaty A. Reduced Heart Rate Response during Drug-Induced Stress Is Related to the Severity of Perfusion Defect. World J Cardiovasc Dis. 2021; 11(11):539-51. [DOI:10.4236/wjcd.2021.1111051] [DOI:10.4236/wjcd.2021.1111051]
14. Hendel RC, Berman DS, Di Carli MF, Heidenreich PA, Henkin RE, Pellikka PA, et al. ACCF/ASNC/ACR/AHA/ASE/SCCT/SCMR/SNM 2009 appropriate use criteria for cardiac radionuclide imaging: A report of the american college of cardiology foundation appropriate use criteria task force, the American society of nuclear cardiology, the American college of radiology, the American heart association, the American society of echocardiography, the society of cardiovascular computed tomography, the society for cardiovascular magnetic resonance, and the society of nuclear medicine. J Am Coll Cardiol. 2009; 53(23):2201-29. [DOI:10.1016/j.jacc.2009.02.013] [PMID] [DOI:10.1016/j.jacc.2009.02.013]
15. Prvulovich E, Metcalfe MJ. Nuclear cardiology in the UK: Activity and practice 1997. Eur J Nucl Med Mol Imaging. 2002; 29(4):553-8. [DOI:10.1007/s00259-001-0729-6] [PMID] [DOI:10.1007/s00259-001-0729-6]
16. Andrus BW, Welch HG. Medicare services provided by cardiologists in the United States: 1999-2008. Circ Cardiovasc Qual Outcomes. 2012; 5(1):31-6. [DOI:10.1161/CIRCOUTCOMES.111.961813] [PMID] [DOI:10.1161/CIRCOUTCOMES.111.961813]
17. Zakavi SR. [Nuclear cardiology in Iran in 2002 (Persian)]. Iran J Nucl Med. 2004; 12(1):73-7. [Link]
18. Bonow RO, Mann DL, Zipes DP, Libby P. Braunwald's heart disease e-book: A textbook of cardiovascular medicine. Edinburgh: Elsevier Health Sciences; 2011. [Link]
19. Mathur S, Shah AR, Ahlberg AW, Katten DM, Heller GV. Blunted heart rate response as a predictor of cardiac death in patients undergoing vasodilator stress technetium-99m sestamibi gated SPECT myocardial perfusion imaging. J Nucl Cardiol. 2010; 17(4):617-24. [DOI:10.1007/s12350-010-9242-2] [PMID] [DOI:10.1007/s12350-010-9242-2]
20. AlJaroudi W, Anokwute C, Fughhi I, Campagnoli T, Wassouf M, Vij A, et al. The prognostic value of heart rate response during vasodilator stress myocardial perfusion imaging in patients with end-stage renal disease undergoing renal transplantation. J Nucl Cardiol. 2019; 26(3):814-22. [PMID] [DOI:10.1007/s12350-017-1061-2]
21. Aaty A, El-DeenZaky A, Lotfy M, Fathy A. Heart rate response to dypiridamole stress in relation to perfusion and function during gated technecium Tc99 M sestamibi spect study. J Cardiol Curr Res. 2015; 2(3):00063. [DOI:10.15406/jccr.2015.02.00063] [DOI:10.15406/jccr.2015.02.00063]
22. De Lorenzo A, Lima RS. Influence of chronic renal failure on the heart rate response to dipyridamole in patients undergoing myocardial perfusion SPECT. J Nucl Cardiol. 2008; 15(2):193-200. [DOI:10.1016/j.nuclcard.2007.10.006] [PMID] [DOI:10.1016/j.nuclcard.2007.10.006]
23. Gorur GD, Ciftci EA, Kozdag G, Isgoren S, Oc MA, Haksal C, et al. Reduced heart rate response to dipyridamole in patients undergoing myocardial perfusion SPECT. Ann Nucl Med. 2012; 26(8):609-15. [DOI:10.1007/s12149-012-0618-z] [PMID] [DOI:10.1007/s12149-012-0618-z]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Owned by Qom University of Medical Sciences
Published by Qom University of Medical Sciences Press
eISSN: 2717-0357
Email: jvessels[at]muq.ac.ir
j.vessels.circul[at]gmail.com
