Volume 4, Issue 1 (Winter 2023)                   J Vessel Circ 2023, 4(1): 29-36 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kargarfard M, Soltani M M, Soltani M, Hojjat S, Seyedebrahimi R, Ababzadeh S et al . Investigating the Outcome of Cardiac Rehabilitation Program on Plasma Adiponectin Levels and Lipid Profile in Patients With Coronary Heart Disease. J Vessel Circ 2023; 4 (1) :29-36
URL: http://jvessels.muq.ac.ir/article-1-251-en.html
1- Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran.
2- Department of Vice President of Management and Resources Development, Qom University of Medical Sciences, Qom, Iran.
3- Department of Sports Biomechanics, Faculty of Sports Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
4- Department of Exercise Physiology, Faculty of Sport Sciences, Karaj Branch, Islamic Azad University, Karaj, Iran.
5- Cellular and Molecular Research Center, Qom University of Medical Science, Qom, Iran.
6- Department of Tissue Engineering, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
7- Department of Exercise Physiology, Faculty of Sport Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Abstract:   (312 Views)
Background and Aim: A cardiac rehabilitation program (CRP) is a non-pharmacological treatment for patients with coronary heart disease (CHD). The present study investigates the effects of CRP on adiponectin and lipid profiles in CHD patients for 8 weeks.
Materials and Methods: A total of 60 patients with CHD were divided into 2 groups: the exercise group (EG), who completed a series of CRP (3 times a week, in the morning at 60%-85% of maximum heart rate, lasted 45-60 min for 8 weeks), and a control group who did not exercise during 8 weeks. In each group, 16 patients were female and 14 patients were male (n=30). The body mass index, waist-to-hip ratio, and cardiorespiratory variables were determined at baseline after the 8 weeks. Medication and diet remained unchanged in both groups during this period. The data were evaluated by the independent t-tests via the SPSS software, version 26. The significant level was considered P<0.05.
Results: The results showed a significant difference in anthropometric and cardiorespiratory variables, except in resting diastolic blood pressure between the two groups after CRP. Also, a significant decrease was observed in the exercise group for serum total cholesterol, low-density lipoprotein, and triglycerides levels, resting diastolic blood pressure, body weight, body mass index, waist-to-hip ratio, and a significant increase for functional capacity, high-density lipoprotein, and adiponectin levels compared to baseline (P<0.05). The high-density lipoprotein-cholesterol level in the exercise group was higher than the control group after CRP (P<0.05).
Conclusion: Cardiac rehabilitation based on aerobic exercise training may improve plasma lipid profile and adiponectin level in CHD patients, in the absence of changes in diet or medication.
Full-Text [PDF 992 kb]   (153 Downloads) |   |   Full-Text (HTML)  (112 Views)  
Type of Study: Research | Subject: cardiovascular diseases
Received: 2023/03/7 | Accepted: 2023/07/24 | Published: 2023/03/1

References
1. Amiri P, Mohammadzadeh-Naziri K, Abbasi B, Cheraghi L, Jalali-Farahani S, Momenan AA, et al. Smoking habits and incidence of cardiovascular diseases in men and women: findings of a 12 year follow up among an urban Eastern-Mediterranean population. BMC Public Health. 2019; 19(1):1042.[DOI:10.1186/s12889-019-7390-0] [PMID] [DOI:10.1186/s12889-019-7390-0]
2. Sadeghi M, kargarfard M, Yazdekhasti S, Golabchi A. Effect of cardiac rehabilitation program on systolic function and Left Ventricular mass in patient after myocardial infarction post revascularization. J Res Med Sci. 2012; 17(4):1-5. [Link]
3. Sattar N, Wannamethee G, Sarwar N, Tchernova J, Cherry L, Wallace AM, et al. Adiponectin and coronary heart disease: A prospective study and meta-analysis. Circulation. 2006; 114(7):623-9. [DOI:10.1161/CIRCULATIONAHA.106.618918] [PMID] [DOI:10.1161/CIRCULATIONAHA.106.618918]
4. Souza RA, Alves CMR, de Oliveira CSV, Reis AF, Carvalho AC. Circulating levels of adiponectin and extent of coronary artery disease in patients undergoing elective coronary angiography. Braz J Med Biol Res. 2017; 51(2):e6738. [DOI:10.1590/1414-431x20176738] [PMID] [DOI:10.1590/1414-431x20176738]
5. Bloemer J, Pinky PD, Govindarajulu M, Hong H, Judd R, Amin RH, et al. Role of adiponectin in central nervous system disorders. Neural Plast. 2018; 2018:4593530. [DOI:10.1155/2018/4593530]] [PMID] [DOI:10.1155/2018/4593530]
6. Golabchi A, Basati F, Kargarfard M, Sadeghi M. Can cardiac rehabilitation programs improve functional capacity and left ventricular diastolic function in patients with mechanical reperfusion after ST elevation myocardial infarction? A double-blind clinical trial. ARYA Atheroscler. 2012; 8(3):125-9. [PMID]
7. Alves AJ, Viana JL, Cavalcante SL, Oliveira NL, Duarte JA, Mota J, et al. Physical activity in primary and secondary prevention of cardiovascular disease: Overview updated. World J Cardiol. 2016; 8(10):575-83. [DOI:10.4330/wjc.v8.i10.575] [PMID] [DOI:10.4330/wjc.v8.i10.575]
8. Kargarfard M, Rouzbehani R, Basati F. Effects of exercise rehabilitation on blood pressure of patients after myocardial infarction. Int J Prev Med. 2010; 1(2):124-30. [PMID]
9. Wang X, You T, Murphy K, Lyles MF, Nicklas BJ. Addition of exercise increases plasma adiponectin and release from adipose tissue. Med Sci Sports Exerc. 2015; 47(11):2450-5. [DOI:10.1249/MSS.0000000000000670] [PMID] [DOI:10.1249/MSS.0000000000000670]
10. Kim SJ, Yoon ES, Jung SY, Kim DY. Effect of uphill walking on browning factor and high molecular weight-adiponectin in postmenopausal women. J Exerc Rehabil. 2020; 16(3):265-71. [DOI:10.12965/jer.2040334.167] [PMID] [DOI:10.12965/jer.2040334.167]
11. Moghadasi M, Nouri R, Nematollah Zadeh Mahani MA, Karami Banari L. [Effects of 12 weeks walking on plasma adiponectin concentration in postmenopausal women with breast cancer (Persian)]. Iran J Endocrinol Metab. 2012; 14(1):47-52. [Link]
12. Yazigi Solis M, Artioli GG, Montag E, de Salles Painelli V, Saito FL, Lima FR, et al. The liposuction-induced effects on adiponectin and selected cytokines are not affected by exercise training in women. Int J Endocrinol. 2014; 2014:315382.[DOI:10.1155/2014/315382] [PMID] [DOI:10.1155/2014/315382]
13. Sadeh MR, Sharifatpour R. The effect of eight weeks of aerobic exercise on balance function and physiological cost index in Multiple Sclerosis patients. J. Community Health Res. 2020. [DOI:10.18502/jchr.v9i4.4980] [DOI:10.18502/jchr.v9i4.4980]
14. Swainson MG, Ingle L, Carroll S. Cardiorespiratory fitness as a predictor of short-term and lifetime estimated cardiovascular disease risk. Scand J Med Sci Sports. 2019; 29(9):1402-13. [DOI:10.1111/sms.13468] [PMID] [DOI:10.1111/sms.13468]
15. Gariballa S, Alkaabi J, Yasin J, Al Essa A. Total adiponectin in overweight and obese subjects and its response to visceral fat loss. BMC Endocr Disord. 2019; 19(1):55. [DOI:10.1186s12902-019-0386-z]] [PMID] [DOI:10.1186/s12902-019-0386-z]
16. Yanai H, Yoshida H. Beneficial effects of adiponectin on glucose and lipid metabolism and atherosclerotic progression: mechanisms and perspectives. Int J Mol Sci. 2019; 20(5):1190. [PMID] [DOI:10.3390/ijms20051190]
17. Fadaei R, Moradi N, Kazemi T, Chamani E, Azdaki N, Moezibady SA, et al. Decreased serum levels of CTRP12/adipolin in patients with coronary artery disease in relation to inflammatory cytokines and insulin resistance. Cytokine. 2019; 113:326-31. [PMID] [DOI:10.1016/j.cyto.2018.09.019]
18. Stojanovic S, Ilic MD, Ilic S, Saric S, Stojanovic S, Petrovic V. Impact of Adiponectin resistance on coronary artery disease severity. Niger J Clin Pract. 2021; 24(8):1240-6. [DOI:10.4103/njcp.njcp_611_19] [PMID] [DOI:10.4103/njcp.njcp_611_19]
19. Orlando A, Nava E, Giussani M, Genovesi S. Adiponectin and cardiovascular risk. From pathophysiology to clinic: Focus on children and adolescents.Int J Mol Sci. 2019; 20(13):3228. [DOI:10.3390/ijms20133228] [PMID] [DOI:10.3390/ijms20133228]
20. Shibata R, Ouchi N, Murohara T. Adiponectin and cardiovascular disease. Circ J. 2009; 73(4):608-14. [PMID] [DOI:10.1253/circj.CJ-09-0057]
21. Esain I, Rodriguez-Larrad A, Bidaurrazaga-Letona I, Gil SM. Exercise cessation in active older adults: Effects on inflammatory markers and adiponectin. Geriatr Gerontol Int. 2020; 20(5):494-9. [DOI:10.1111/ggi.13907] [PMID] [DOI:10.1111/ggi.13907]
22. Marcell TJ, McAuley KA, Traustadóttir T, Reaven PD. Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism. 2005; 54(4):533-41. [DOI:10.1016/j.metabol.2004.11.008] [PMID] [DOI:10.1016/j.metabol.2004.11.008]
23. Parida S, Siddharth S, Sharma D. Adiponectin, obesity, and cancer: Clash of the bigwigs in health and disease. Int J Mol Sci. 2019; 20(10):2519. [DOI:10.3390/ijms20102519] [PMID] [DOI:10.3390/ijms20102519]
24. Yokoyama H, Emoto M, Araki T, Fujiwara S, Motoyama K, Morioka T, et al. Effect of aerobic exercise on plasma adiponectin levels and insulin resistance in type 2 diabetes. Diabetes Care. 2004; 27(7):1756-8. [DOI:10.2337/diacare.27.7.1756] [PMID] [DOI:10.2337/diacare.27.7.1756]
25. Becic T, Studenik C, Hoffmann G. Exercise increases adiponectin and reduces leptin levels in prediabetic and diabetic individuals: Systematic review and meta-analysis of randomized controlled trials. Med sci. 2018; 6(4):97. [DOI:10.3390/medsci6040097] [PMID] [DOI:10.3390/medsci6040097]
26. Nikkar H, Rshidlamir A, Khajei R, Barjaste A, Vazifedoost M. Effects of 8 Weeks of Combined Rehabilitation Training on Plasma Levels of Leptin, Adiponectin, and Resistin‎ in Middle-Aged Men after CABG. Med Lab J. 2023; 17(1):20-6. [Link]
27. Bruning RS, Sturek M. Benefits of exercise training on coronary blood flow in coronary artery disease patients. Prog Cardiovasc Dis. 2015; 57(5):443-53. [DOI:10.1016/j.pcad.2014.10.006] [PMID] [DOI:10.1016/j.pcad.2014.10.006]
28. Boulghobra D, Dubois M, Alpha-Bazin B, Coste F, Olmos M, Gayrard S, et al. Increased protein S-nitrosylation in mitochondria: a key mechanism of exercise-induced cardioprotection. Basic Res. Cardiol. 2021; 116(1):66. [DOI:10.1007/s00395-021-00906-3]] [PMID] [DOI:10.1007/s00395-021-00906-3]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | Journal of Vessels and Circulation

Designed & Developed by : Yektaweb