Volume 3, Issue 3 (Summer 2022)                   J Vessel Circ 2022, 3(3): 147-158 | Back to browse issues page

Ethics code: IR.MUQ.AEC.1400.007

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Salimi H R, Haghighi A H, Ababzadeh S, Marefati H. Studying the Histopathological Effects of Aerobic Training Along With Vitamin E Consumption in the Cardiac of Methamphetamine-dependent Rats. J Vessel Circ 2022; 3 (3) :147-158
URL: http://jvessels.muq.ac.ir/article-1-240-en.html
Studying the Histopathological Effects of Aerobic Training Along With Vitamin E Consumption in the Cardiac of Methamphetamine-dependent Rats
Hamid Reza Salimi1 , Amir Hossein Haghighi * 2, Shima Ababzadeh3 , Hamid Marefati4
1- Department of Exercise Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran., قم،خ سوم خرداد،خ بعثت پنج،12 متری فرهنگیان،کوچه 13 پلاک 1
2- Department of Exercise Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran.
3- Department of Anatomy, Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran, قم،دانشگاه علوم پزشکی قم،دانشکده پزشکی
4- Department of Exercise Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran., سبزوار،توحید شهر.دانشگاه حکیم سبزواری،دانشکده تربیت بدنی
Abstract:   (926 Views)
Background and Aim: Methamphetamine abuse causes tachycardia, tachypnea (hyperventilation), high blood pressure, rupture of heart vessels, and an increase of fibrotic tissue in the human heart. This study aimed to investigate the histopathological effects of aerobic training and vitamin E consumption on the heart following the consumption of methamphetamine in male rats.
Materials and Methods: In this research, 54 adult rats weighing 200-210 g were divided into 6 groups, saline, addicted (sham), addicted+oral paraffin (AP), addicted+supplement (AS), addicted+aerobic training (AAT), addicted+aerobic training+supplement (AATS). After 23 days of methamphetamine injection, moderate-intensity aerobic training was performed for 6 weeks and 150 mg/kg of vitamin E was administered by gastric gavage. After this period, the rats were dissected and their hearts were removed. The data were analyzed using one-way ANOVA methods at P<0.05.
Results: The morphological investigation showed a difference between the two groups of sham and AP with the saline, AS, AAT, and AATS in the space between the endocardium, congestion, and vascular rupture. There was a difference in the hypertrophy of muscle fibers between the sham and AP with the saline, AS, AAT, and AATS in the morphometric investigation.
Conclusion: It can be said that methamphetamine causes pathological hypertrophy of cardiomyocytes and destruction and rupture of blood vessels, and aerobic training along with vitamin E consumption causes physiological cardiac hypertrophy. Regarding the effect of vitamin E alone on the type of cardiac hypertrophy and vascular changes, further studies are needed.
Keywords: Methamphetamine, Exercise, Vitamin E, Hypertrophy, Aerobic training
Full-Text [PDF 1412 kb]   (191 Downloads)    
Type of Study: Research | Subject: cardiovascular diseases
Received: 2022/12/26 | Accepted: 2023/01/24 | Published: 2022/11/1
References
1. Shafiei A, Haghighi AH, Askari R, Keyhani A, Nabavizadeh MS, Asadi-Shekaari M. Effects of moderate-intensity interval training on gene expression and antioxidant status in the hippocampus of methamphetamine-dependent rats. Neurotox Res. 2022; 40(5):1455-63. [DOI:10.1007/s12640-022-00532-4] [PMID] [DOI:10.1007/s12640-022-00532-4]
2. Reddy PKV, Ng TMH, Oh EE, Moady G, Elkayam U. Clinical characteristics and management of methamphetamine-associated cardiomyopathy: State-of-the-art review. J Am Heart Assoc. 2020; 9(11):e016704. [DOI:10.1161/JAHA.120.016704] [PMID] [PMCID] [DOI:10.1161/JAHA.120.016704]
3. Courtney KE, Ray LA. Methamphetamine: An update on epidemiology, pharmacology, clinical phenomenology, and treatment literature. Drug Alcohol Depend. 2014; 143:11-21. [DOI:10.1016/j.drugalcdep.2014.08.003] [PMID] [PMCID] [DOI:10.1016/j.drugalcdep.2014.08.003]
4. Karch SB. The unique histology of methamphetamine cardiomyopathy: A case report. Forensic Sci Int. 2011; 212(1-3):e1-4. [DOI:10.1016/j.forsciint.2011.04.028] [PMID] [DOI:10.1016/j.forsciint.2011.04.028]
5. Akhgari M, Mobaraki H, Etemadi-Aleagha A. Histopathological study of cardiac lesions in methamphetamine poisoning-related deaths. Daru. 2017; 25(1):5. [DOI:10.1186/s40199-017-0170-4] [PMID] [PMCID] [DOI:10.1186/s40199-017-0170-4]
6. Shahrabadi H, Haghighi AH, Askari R, Asadi-Shekaari M, Souza DC, Gentil P. Effect of high-intensity interval training on cardiac apoptosis markers in methamphetamine-dependent rats. Curr Issues Mol Biol. 2022; 44(7):3030-8.[DOI:10.3390/cimb44070209] [PMID] [PMCID] [DOI:10.3390/cimb44070209]
7. Yazdanparast Chaharmahali B, Azarbayjani MA, Peeri M, Farzanegi Arkhazloo P. Increased expression of bax and bcl2 apoptosis biomarkers in the heart of old female rats after interval training and curcumin consumption. Jorjani Biomed J. 2018; 6(4):40-52. [DOI:10.29252/jorjanibiomedj.6.4.40] [DOI:10.29252/jorjanibiomedj.6.4.40]
8. He F, Li J, Liu Z, Chuang CC, Yang W, Zuo L. Redox mechanism of reactive oxygen species in training. Front physiol. 2016; 7:486. [DOI:10.3389/fphys.2016.00486] [DOI:10.3389/fphys.2016.00486]
9. Nordberg J, Arnér ES. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic Biol Med. 2001; 31(11):1287-312. [DOI:10.1016/S0891-5849(01)00724-9] [PMID] [DOI:10.1016/S0891-5849(01)00724-9]
10. Redza-Dutordoir M, Averill-Bates DA. Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta. 2016; 1863(12):2977-92. [DOI:10.1016/j.bbamcr.2016.09.012] [PMID] [DOI:10.1016/j.bbamcr.2016.09.012]
11. Ghafori SS, Zirak Javanmard M, Meghrazi K, Karimipour M, Peirouvi T. Protective effects of vitamin E on heart and testis histology following MDMA (Ecstasy) exposure in mice. Int J High Risk Behav Addict. 2019; 8(4):e84212. [DOI:10.5812/ijhrba.84212] [DOI:10.5812/ijhrba.84212]
12. Du X, Jiang S, Bo L, Liu J, Zeng X, Xie Y, et al. Combined effects of vitamin E and omega-3 fatty acids on protecting ambient PM2.5-induced cardiovascular injury in rats. Chemosphere. 2017; 173:14-21.[DOI:10.1016/j.chemosphere.2017.01.042] [PMID] [DOI:10.1016/j.chemosphere.2017.01.042]
13. Groman SM, Rich KM, Smith NJ, Lee D, Taylor JR. Chronic exposure to methamphetamine disrupts reinforcement-based decision making in rats. Neuropsychopharmacology. 2018; 43(4):770-80. [DOI:10.1038/npp.2017.159] [PMID] [PMCID] [DOI:10.1038/npp.2017.159]
14. Ayinde OC, Ogunnowo S, Ogedegbe RA. Influence of vitamin C and vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats. BMC Pharmacol Toxicol. 2012; 13:17. [DOI:10.1186/2050-6511-13-17] [PMID] [PMCID] [DOI:10.1186/2050-6511-13-17]
15. Høydal MA, Wisløff U, Kemi OJ, Ellingsen O. Running speed and maximal oxygen uptake in rats and mice: Practical implications for exercise training. Eur J Cardiovasc Prev Rehabil. 2007; 14(6):753-60. [DOI:10.1097/HJR.0b013e3281eacef1] [PMID] [DOI:10.1097/HJR.0b013e3281eacef1]
16. Sedaghat M, Choobineh S, Ravasi AA. Taurine with combined aerobic and resistance exercise training alleviates myocardium apoptosis in STZ-induced diabetes rats via Akt signaling pathway. Life Sci. 2020; 258:118225. [DOI:10.1016/j.lfs.2020.118225] [PMID] [DOI:10.1016/j.lfs.2020.118225]
17. Shimojo GL, da Silva Dias D, Malfitano C, Sanches IC, Llesuy S, Ulloa L, et al. Combined aerobic and resistance exercise training improve hypertension associated with menopause. Front Physiol. 2018; 9:1471. [DOI:10.3389/fphys.2018.01471] [PMID] [PMCID] [DOI:10.3389/fphys.2018.01471]
18. Kaye S, Darke S, Duflou J. Methylenedioxymethamphetamine (MDMA)-related fatalities in Australia: Demographics, circumstances, toxicology and major organ pathology. Drug Alcohol Depend. 2009; 104(3):254-61./ [DOI:10.1016/j.drugalcdep.2009.05.016] [PMID] [DOI:10.1016/j.drugalcdep.2009.05.016]
19. Sun X, Wang Y, Xia B, Li Z, Dai J, Qiu P, et al. Methamphetamine produces cardiac damage and apoptosis by decreasing melusin. Toxicol Appl Pharmacol. 2019; 378:114543. [DOI:10.1016/j.taap.2019.03.015] [PMID] [DOI:10.1016/j.taap.2019.03.015]
20. Cecchi F, Sgalambro A, Baldi M, Sotgia B, Antoniucci D, Camici PG, et al. Microvascular dysfunction, myocardial ischemia, and progression to heart failure in patients with hypertrophic cardiomyopathy. J Cardiovasc Transl Res. 2009; 2(4):452-61. [DOI:10.1007/s12265-009-9142-5] [PMID] [DOI:10.1007/s12265-009-9142-5]
21. Nakamura M, Sadoshima J. Mechanisms of physiological and pathological cardiac hypertrophy. Nat Rev Cardiol. 2018; 15(7):387-407. [DOI:10.1038/s41569-018-0007-y] [PMID] [DOI:10.1038/s41569-018-0007-y]
22. Turkbey EB, McClelland RL, Kronmal RA, Burke GL, Bild DE, Tracy RP, et al. The impact of obesity on the left ventricle: The Multi-Ethnic Study of Atherosclerosis (MESA). JACC Cardiovasc Imaging. 2010; 3(3):266-74. [DOI:10.1016/j.jcmg.2009.10.012] [PMID] [PMCID] [DOI:10.1016/j.jcmg.2009.10.012]
23. Petridis L, Kneffel Z, Kispéter Z, Horváth P, Sidó Z, Pavlik G. Echocardiographic characteristics in adolescent junior male athletes of different sport events. Acta Physiol Hung. 2004; 91(2):99-109. [DOI:10.1556/APhysiol.91.2004.2.2] [PMID] [DOI:10.1556/APhysiol.91.2004.2.2]
24. Vella CA, Allison MA, Cushman M, Jenny NS, Miles MP, Larsen B, et al. Physical activity and adiposity-related inflammation: The MESA. Med Sci Sports Exerc. 2017; 49(5):915-21. [DOI:10.1249/MSS.0000000000001179] [PMID] [PMCID] [DOI:10.1249/MSS.0000000000001179]
25. Ababzadeh S, Iravani A, Fallahian F, Aghamiri SM. Histological and morphological studies of cardiac cells in response to aerobic trainingand rosemary extract in rat model of aging. J Morphological Sci. 2018; 35(04):266-71. [DOI:10.1055/s-0038-1676778] [DOI:10.1055/s-0038-1676778]
26. Packard RR, Libby P. Inflammation in atherosclerosis: From vascular biology to biomarker discovery and risk prediction. Clin Chem. 2008; 54(1):24-38. [DOI:10.1373/clinchem.2007.097360] [PMID] [DOI:10.1373/clinchem.2007.097360]
27. Liu HB, Yuan WX, Wang QY, Wang YX, Cao HW, Xu J, et al. Carotid arterial stiffness and hemodynamic responses to acute cycling intervention at different times during 12-week supervised exercise training period. Biomed Res Int. 2018; 2018:2907548. [DOI:10.1155/2018/2907548] [PMID] [PMCID] [DOI:10.1155/2018/2907548]
28. Jenkins NT, McKenzie JA, Damcott CM, Witkowski S, Hagberg JM. Endurance exercise training effects on body fatness, VO2max, HDL-C subfractions, and glucose tolerance are influenced by a PLIN haplotype in older Caucasians. J Appl Physiol (1985). 2010; 108(3):498-506. [DOI:10.1152/japplphysiol.01018.2009] [PMID] [PMCID] [DOI:10.1152/japplphysiol.01018.2009]
29. Mehranjani MS, Taefi R. The protective role of vitamin E on the testicular tissue in rats exposed to sodium arsenite during the prenatal stage till sex maturity: A stereological analysis. Iranian Journal of Reproductive Medicine. 2012; 10(6):571. [PMID] [PMCID]
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