Volume 2, Issue 1 And Supplement (Winter 2021)
J Vessel Circ 2021, 2(1 And Supplement): 39-39 |
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Simani L, Ramezani M, Fazeli B, Roozbeh M. Vitamin D Supplementation in Acute Ischemic Stroke. J Vessel Circ 2021; 2 (1) :39-39
URL: http://jvessels.muq.ac.ir/article-1-130-en.html
URL: http://jvessels.muq.ac.ir/article-1-130-en.html
1- Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Departmeny of Clinical Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2- Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Departmeny of Clinical Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Abstract: (812 Views)
Background and Aim: Vitamin D deficiency was associated with an increased risk of stroke. Clinical studies have reported improved neurological outcomes in patients who were taking vitamin D supplements. This study proposed to investigate the effect of intramuscular vitamin D treatment in patients with acute ischemic stroke on neurological outcomes, and inflammatory marker levels.
Materials and Methods: seventy-three patients with AIS included in the study and were allocated randomly into single dose 300000 UI an intramuscular vitamin D group or a control group. Serum vitamin D concentration, IL-6 and tumor necrosis factor-α (TNF-α) levels, as primary outcomes, and the Modified Ranking Scale (MRS), the National Institute of Health Stroke Scale (NIHSS) and the Mini-Mental State Examination (MMSE), as secondary outcomes, were measured at the base line and at the end of the study. (6 weeks)
Results: Eventually, 24 patients with AIS completed the intervention study. A single dose of 300000 UI increased vitamin D level and there were reverse correlation between level of serum vitamin D and NIHSS and TNF-α after taking vitamin D. However, no statistically significant effect of vitamin D on the TNF-α and IL-6 levels and on neurological score as compare to control.
Conclusion: Further randomized controlled trials are urgently needed to prove whether vitamin D supplementation reduces the incidence of strokes, improves the outcome of post-stroke patients, and elucidate the relationship between the timing of treatment with calcitriol and neuroprotection.
Materials and Methods: seventy-three patients with AIS included in the study and were allocated randomly into single dose 300000 UI an intramuscular vitamin D group or a control group. Serum vitamin D concentration, IL-6 and tumor necrosis factor-α (TNF-α) levels, as primary outcomes, and the Modified Ranking Scale (MRS), the National Institute of Health Stroke Scale (NIHSS) and the Mini-Mental State Examination (MMSE), as secondary outcomes, were measured at the base line and at the end of the study. (6 weeks)
Results: Eventually, 24 patients with AIS completed the intervention study. A single dose of 300000 UI increased vitamin D level and there were reverse correlation between level of serum vitamin D and NIHSS and TNF-α after taking vitamin D. However, no statistically significant effect of vitamin D on the TNF-α and IL-6 levels and on neurological score as compare to control.
Conclusion: Further randomized controlled trials are urgently needed to prove whether vitamin D supplementation reduces the incidence of strokes, improves the outcome of post-stroke patients, and elucidate the relationship between the timing of treatment with calcitriol and neuroprotection.
Type of Study: Research |
Subject:
stroke
Received: 2021/09/6 | Accepted: 2021/02/28 | Published: 2021/02/28
Received: 2021/09/6 | Accepted: 2021/02/28 | Published: 2021/02/28
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Email: jvessels[at]muq.ac.ir
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