Volume 2, Issue 3 (Summer 2021)
J Vessel Circ 2021, 2(3): 115-120 |
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Arjmandnia M H, Vahedian M, Yousefi M, Rezvan S, Habibi S, Motiei Langroudi S M, et al . Investigating the Relationship Between Congenital Heart Disease in Fetal Echocardiography and High Nuchal Translucency Size in Fetal Ultrasound. J Vessel Circ 2021; 2 (3) :115-120
URL: http://jvessels.muq.ac.ir/article-1-117-en.html
URL: http://jvessels.muq.ac.ir/article-1-117-en.html
Mohammad Hossein Arjmandnia1 
, Mostafa Vahedian2 , Mmaryam Yousefi * 3, Sajjad Rezvan4 , Sima Habibi5 , Seyed Mehrdad Motiei Langroudi6 , Enayatollah Noori1 , Meysam Feizollahjani1 , Mohammad Hossein Assi1
, Mostafa Vahedian2 , Mmaryam Yousefi * 3, Sajjad Rezvan4 , Sima Habibi5 , Seyed Mehrdad Motiei Langroudi6 , Enayatollah Noori1 , Meysam Feizollahjani1 , Mohammad Hossein Assi1
1- Department of Pediatrics, School of Medicine, Hazrat-e Fatemeh Masoumeh Hospital, Qom University of Medical Sciences, Qom, Iran.
2- Department of Family and Community Medicine, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
3- Department of Obstetrics and Gynecology, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
4- Department of Radiology, Ali Ebn-e Abitaleb Hospital, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
5- Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran.
6- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Family and Community Medicine, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
3- Department of Obstetrics and Gynecology, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
4- Department of Radiology, Ali Ebn-e Abitaleb Hospital, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
5- Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran.
6- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract: (1283 Views)
Background and Aim: This study aimed to investigate the relationship between congenital heart disease found in fetal echocardiography with high nuchal translucency (NT) size found in fetal ultrasound in mothers referring to Hazrat Masoumeh Hospital, Qom City, Iran, in 2019.
Materials and Methods: In this analytical study, information on all pregnant women who underwent ultrasound screening in the first trimester of pregnancy and their NT size was determined. Also, information obtained from fetal echocardiographic results, which were then subjected to fetal echocardiography, was extracted from the files. Then, the relationship between cardiovascular abnormalities with NT size and variables such as birth, weight, gestational age, and gender in these mothers were entered into a checklist and examined. Finally, the relationship between congenital heart disease and NT size was investigated using the t-test.
Results: The Mean±SD NT size of 152 neonates without cardiovascular disease was 1.67±0.3 mm, and the Mean±SD size was 1.86±0.5 mm in 40 neonates with cardiovascular disease. Also, a statistically significant relationship was found between NT size and cardiovascular disease in neonates (P=0.00). There was also a statistically significant relationship was not found between neonatal gender (P=0.71), maternal age (P=0.88), as well as between number of pregnancies (P=0.26), NT size (P=0.76), type of pregnancy (P=0.63), gestational age (P=0.4), and NT size on ultrasound.
Conclusion: Fetal echocardiography is a non-invasive method suitable for the early diagnosis of congenital heart disease in high-and low-risk pregnancies. Increased NT size is also associated with cardiovascular disease in infants.
Materials and Methods: In this analytical study, information on all pregnant women who underwent ultrasound screening in the first trimester of pregnancy and their NT size was determined. Also, information obtained from fetal echocardiographic results, which were then subjected to fetal echocardiography, was extracted from the files. Then, the relationship between cardiovascular abnormalities with NT size and variables such as birth, weight, gestational age, and gender in these mothers were entered into a checklist and examined. Finally, the relationship between congenital heart disease and NT size was investigated using the t-test.
Results: The Mean±SD NT size of 152 neonates without cardiovascular disease was 1.67±0.3 mm, and the Mean±SD size was 1.86±0.5 mm in 40 neonates with cardiovascular disease. Also, a statistically significant relationship was found between NT size and cardiovascular disease in neonates (P=0.00). There was also a statistically significant relationship was not found between neonatal gender (P=0.71), maternal age (P=0.88), as well as between number of pregnancies (P=0.26), NT size (P=0.76), type of pregnancy (P=0.63), gestational age (P=0.4), and NT size on ultrasound.
Conclusion: Fetal echocardiography is a non-invasive method suitable for the early diagnosis of congenital heart disease in high-and low-risk pregnancies. Increased NT size is also associated with cardiovascular disease in infants.
Type of Study: Research |
Subject:
cardiovascular diseases
Received: 2021/08/4 | Accepted: 2021/09/5 | Published: 2021/10/2
Received: 2021/08/4 | Accepted: 2021/09/5 | Published: 2021/10/2
References
1. Arjmandnia MH, Yousefi M, Rezvan S, Vahedian M, Noori E, Mohammadi A, et al. Evaluation of congenital heart diseases in neonates with diabetic mothers who referred to teaching hospitals in Qom, Iran. J Vessel Circ. 2020; 1(1):33-6. [DOI:10.29252/jvesselcirc.1.1.33] [DOI:10.29252/jvesselcirc.1.1.33]
2. Zhang YF, Zeng XL, Zhao EF, Lu HW. Diagnostic value of fetal echocardiography for congenital heart disease: A systematic review and meta-analysis. Medicine (Baltimore). 2015; 94(42):e1759. [DOI:10.1097/MD.0000000000001759] [PMID] [PMCID] [DOI:10.1097/MD.0000000000001759]
3. Liu H, Zhou J, Feng QL, Gu HT, Wan G, Zhang HM, et al. Fetal echocardiography for congenital heart disease diagnosis: A meta-analysis, power analysis and missing data analysis. Eur J Prev Cardiol. 2015; 22(12):1531-47. [DOI:10.1177/2047487314551547] [PMID] [DOI:10.1177/2047487314551547]
4. Killen SA, Mouledoux JH, Kavanaugh-McHugh A. Pediatric prenatal diagnosis of congenital heart disease. Curr Opin Pediatr. 2014; 26(5):536-45. [DOI:10.1097/MOP.0000000000000136] [PMID] [DOI:10.1097/MOP.0000000000000136]
5. Vahedian M, Yosefi M, Mohammadi A, Rezvan S, Noori E, Rezaei G, et al. [Evaluation of referral indications for fetal echocardiography in pregnant women referred to echocardiography unit of Masoumeh hospital in the winter of 2018 (Persian)]. Jundishapur Sci Med J. 2019; 18(4):369-77. [DOI:10.22118/jsmj.2019.196900.1784]
6. Rychik J, Ayres N, Cuneo B, Gotteiner N, Hornberger L, Spevak PJ, et al. American society of echocardiography guidelines and standards for performance of the fetal echocardiogram. J Am Soc Echocardiogr. 2004; 17(7):803-10. [DOI:10.1016/j.echo.2004.04.011] [PMID] [DOI:10.1016/j.echo.2004.04.011]
7. Lange LW, Sahn DJ, Allen HD, Goldberg SJ, Anderson C, Giles H. Qualitative real-time cross-sectional echocardiographic imaging of the human fetus during the second half of pregnancy. Circulation. 1980; 62(4):799-806. [DOI:10.1161/01.cir.62.4.799] [PMID] [DOI:10.1161/01.CIR.62.4.799]
8. Oggè G, Gaglioti P, Maccanti S, Faggiano F, Todros T. Prenatal screening for congenital heart disease with four-chamber and outflow-tract views: A multicenter study. Ultrasound Obstet Gynecol. 2006; 28(6):779-84. [DOI:10.1002/uog.3830] [PMID] [DOI:10.1002/uog.3830]
9. No Authors. Cardiac screening examination of the fetus: Guidelines for performing the 'basic' and 'extended basic' cardiac scan. Ultrasound Obstet Gynecol. 2006; 27(1):107-13. [DOI:10.1002/uog.2677] [PMID] [DOI:10.1002/uog.2677]
10. Hyett J, Perdu M, Sharland G, Snijders R, Nicolaides KH. Using fetal nuchal translucency to screen for major congenital cardiac defects at 10-14 weeks of gestation: Population based cohort study. BMJ. 1999; 318(7176):81-5. [DOI:10.1136/bmj.318.7176.81] [PMID] [PMCID] [DOI:10.1136/bmj.318.7176.81]
11. Souka AP, Snijders RJ, Novakov A, Soares W, Nicolaides KH. Defects and syndromes in chromosomally normal fetuses with increased nuchal translucency thickness at 10-14 weeks of gestation. Ultrasound Obstet Gynecol. 1998; 11(6):391-400. [DOI:10.1046/j.1469-0705.1998.11060391.x] [PMID] [DOI:10.1046/j.1469-0705.1998.11060391.x]
12. Snijders RJ, Noble P, Sebire N, Souka A, Nicolaides KH. UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation. Fetal medicine foundation first trimester screening group. Lancet. 1998; 352(9125):343-6. [DOI:10.1016/s0140-6736(97)11280-6] [PMID] [DOI:10.1016/S0140-6736(97)11280-6]
13. American Institute of Ultrasound in Medicine. AIUM practice guideline for the performance of obstetric ultrasound examinations. J Ultrasound Med. 2010; 29(1):157-66. [DOI:10.7863/jum.2010.29.1.157] [PMID] [DOI:10.7863/jum.2010.29.1.157]
14. Carvalho JS, Allan LD, Chaoui R, Copel JA, DeVore GR, Hecher K, et al. ISUOG practice guidelines (updated): Sonographic screening examination of the fetal heart. Ultrasound Obstet Gynecol. 2013; 41(3):348-59. [DOI:10.1002/uog.12403] [PMID] [DOI:10.1002/uog.12403]
15. American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 101: Ultrasonography in pregnancy. Obstet Gynecol. 2009; 113(2 Pt 1):451-61. [DOI:10.1097/AOG.0b013e31819930b0] [PMID] [DOI:10.1097/AOG.0b013e31819930b0]
16. Sekhavat S, Kishore N, Levine JC. Screening fetal echocardiography in diabetic mothers with normal findings on detailed anatomic survey. Ultrasound Obstet Gynecol. 2010; 35(2):178-82. [DOI:10.1002/uog.7467] [PMID] [DOI:10.1002/uog.7467]
17. Muller PR, James A, Feldman K, Herlong JR. Utility of fetal echocardiogram in high-risk patients. Aust N Z J Obstet Gynaecol. 2005; 45(2):117-21. [DOI:10.1111/j.1479-828X.2005.00347.x] [PMID] [DOI:10.1111/j.1479-828X.2005.00347.x]
18. Souka AP, Krampl E, Bakalis S, Heath V, Nicolaides KH. Outcome of pregnancy in chromosomally normal fetuses with increased nuchal translucency in the first trimester. Ultrasound Obstet Gynecol. 2001; 18(1):9-17. [DOI:10.1046/j.1469-0705.2001.00454.x] [PMID] [DOI:10.1046/j.1469-0705.2001.00454.x]
19. Froehlich RJ, Maggio L, Has P, Werner EF, Rouse DJ. Evaluating the performance of ultrasound screening for congenital heart disease: A descriptive cohort study. Am J Perinatol. 2017; 34(9):905-10. [DOI:10.1055/s-0037-1601309] [PMID] [DOI:10.1055/s-0037-1601309]
20. Chu C, Yan Y, Ren Y, Li X, Gui Y. Prenatal diagnosis of congenital heart diseases by fetal echocardiography in second trimester: A Chinese multicenter study. Acta Obstet Gynecol Scand. 2017; 96(4):454-63. [DOI:10.1111/aogs.13085] [PMID] [DOI:10.1111/aogs.13085]
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