Volume 1, Issue 1 (Winter 2020)                   J Vessel Circ 2020, 1(1): 19-27 | Back to browse issues page

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Tabaraii R, Arjmandnia M H, Noori E, Barati A, Rezvan S. Role of imaging in deep vein thrombosis: a review article. J Vessel Circ 2020; 1 (1) :19-27
URL: http://jvessels.muq.ac.ir/article-1-26-en.html
Role of imaging in deep vein thrombosis: a review article
Reihane Tabaraii1 , Mohammad Hosein Arjmandnia2 , Enayatollah Noori * 3, Akram Barati4 , Sajad Rezvan5
1- Department of Internal Medicine, Qom University of Medical Sciences, Qom, Iran
2- Department of Pediatrics, Qom University of Medical Sciences, Qom, Iran
3- Student Research Committee, Qom University of Medical Sciences
4- Department of Research and Technology, Qom University of Medical Sciences
5- Student Research Committee, Rafsanjan University of Medical Sciences
Abstract:   (2354 Views)
Background and Aims: Venous Thrombo Embolism (VTE) refers to the formation of clots in blood vessels. The current study aimed to investigate deep vein thrombosis (DVT) by imaging modalities.
Materials and Methods: In this review study, national databases, including Magiran, SID, IranMedex, as well as international ones, namely databases including PubMed, Google scholar, Scopus, and ISI, were searched for related books and articles.  The keywords included thrombosis, deep vein thrombosis, imaging, and thrombosis detection.
Results: In patients with suspected primary or recurrent deep vein thrombosis, CT venography (CTV) and Magnetic Resonance Venography (MRV) are rarely used on suspicion of iliac vein thrombosis or inferior vena cava (IVC) thrombosis in ultrasound. These examinations have relatively poor reliability, cause adverse side effects of radiation and contrast materials, and are undoubtedly more costly.
 
Conclusion:  As evidenced by the obtained results, different methods are available for the diagnosis of deep vein thrombosis. Moreover, it was revealed that ultrasound imaging is the most reasonable method for initial examination due to its sensitivity, specificity, costs, and adverse effects.
Keywords: Diagnosis, Diagnostic imaging, Venous thrombosis, Deep vein thrombosis
Full-Text [PDF 867 kb]   (746 Downloads) |   |   Full-Text (HTML)  (2179 Views)  
Type of Study: Review | Subject: stroke
Received: 2019/11/19 | Accepted: 2020/01/12 | Published: 2020/01/30
References
1. Kearon C. Natural history of venous thromboembolism. Circulation 2003;107(23 Suppl 1):I22-30. PMID: 12814982 [DOI:10.1161/01.CIR.0000078464.82671.78]
2. Witt DM, Nutescu EA, Haines ST. Venous thromboembolism. Pharmacotherapy: a pathophysiologic approach. 8th ed. New York: McGraw-Hill Medical; 2011. P. 311-52. Link
3. Goldhaber SZ, Bounameaux H. Pulmonary embolism and deep vein thrombosis. Lancet 2102;379(9828):1835-46. PMID: 22494827 [DOI:10.1016/S0140-6736(11)61904-1]
4. Burgazli KM, Atmaca N, Mericliler M, Parahuleva M, Erdogan A, Daebritz SH. Deep vein thrombosis and novel oral anticoagulants: a clinical review. Eur Rev Med Pharmacol Sci 2013;17(23):3123-31. PMID: 24338453
5. Bundens WP, Bergan JJ, Halasz NA, Murray J, Drehobl M. The superficial femoral vein. A potentially lethal misnomer. JAMA 1995;274(16):1296-8. PMID: 7563535 [DOI:10.1001/jama.274.16.1296]
6. Habscheid W, Höhmann M, Wilhelm T, Epping J. Real-time ultrasound in the diagnosis of acute deep venous thrombosis of the lower extremity. Angiology 1990;41(8):599-608. PMID: 2202232 [DOI:10.1177/000331979004100803]
7. Rose SC, Zwiebel WJ, Nelson BD, Priest DL, Knighton RA, Brown JW, et al. Symptomatic lower extremity deep venous thrombosis: accuracy, limitations, and role of color duplex flow imaging in diagnosis. Radiology 1990;175(3):639-44. PMID: 2188293 [DOI:10.1148/radiology.175.3.2188293]
8. Kearon, Clive, et al. "Noninvasive diagnosis of deep venous thrombosis." Annals of internal medicine 128.8 (1998): 663-677.‌ https://annals.org/aim/article-abstract/711330/noninvasive-diagnosis-deep-venous-thrombosis [DOI:10.7326/0003-4819-128-8-199804150-00011]
9. Rose SC, Zwiebel WJ, Murdock LE, Hofmann AA, Priest DL, Knighton RA, et al. Insensitivity of color Doppler flow imaging for detection of acute calf deep venous thrombosis in asymptomatic postoperative patients. J Vasc Interv Radiol 1993;4(1):111-7. PMID: 8425087 [DOI:10.1016/S1051-0443(93)71832-1]
10. Needleman L, Cronan JJ, Lilly MP, Merli GJ, Adhikari S, Hertzberg BS, et al. Ultrasound for lower extremity deep venous thrombosis: multidisciplinary recommendations from the society of radiologists in ultrasound consensus conference. Circulation 2018;137(14):1505-15. PMID: 29610129 [DOI:10.1161/CIRCULATIONAHA.117.030687]
11. Lensing AW, Prandoni P, Brandjes D, Huisman PM, Vigo M, Tomasella G, et al. Detection of deep-vein thrombosis by real-time B-mode ultrasonography. N Engl J Med 1989;320(6):342-5. PMID: 2643771 [DOI:10.1056/NEJM198902093200602]
12. Kassaï B, Boissel JP, Cucherat M, Sonie S, Shah NR, Leizorovicz A. A systematic review of the accuracy of ultrasound in the diagnosis of deep venous thrombosis in asymptomatic patients. Thromb Haemost 2004;91(4):655-66. PMID: 15045125 [DOI:10.1160/TH03-11-0722]
13. Cogo A, Lensing AW, Koopman MM, Piovella F, Siragusa S, Wells PS, et al. Compression ultrasonography for diagnostic management of patients with clinically suspected deep vein thrombosis: prospective cohort study. BMJ 1998;316(7124):17-20. PMID: 9451260 [DOI:10.1136/bmj.316.7124.17]
14. Gibson NS, Schellong SM, Kheir DY, Beyer-Westendorf J, Gallus AS, McRae S, et al. Safety and sensitivity of two ultrasound strategies in patients with clinically suspected deep venous thrombosis: a prospective management study. J Thromb Haemost 2009;7(12):2035-41. PMID: 19817986 [DOI:10.1111/j.1538-7836.2009.03635.x]
15. Heijboer H, Büller HR, Lensing AW, Turpie AG, Colly LP, ten Cate JW. A comparison of real-time compression ultrasonography with impedance plethysmography for the diagnosis of deep-vein thrombosis in symptomatic outpatients. N Engl J Med 1993;329(19):1365-9. PMID: 8413431 [DOI:10.1056/NEJM199311043291901]
16. Goodacre S, Sampson F, Thomas S, van Beek E, Sutton A. Systematic review and meta-analysis of the diagnostic accuracy of ultrasonography for deep vein thrombosis. BMC Med Imaging 2005;5:6. PMID: 16202135 [DOI:10.1186/1471-2342-5-6]
17. Kearon C, Ginsberg JS, Hirsh J. The role of venous ultrasonography in the diagnosis of suspected deep venous thrombosis and pulmonary embolism. Ann Intern Med 1998;129(12):1044-9. PMID: 9867760 [DOI:10.7326/0003-4819-129-12-199812150-00009]
18. Birdwell BG, Raskob GE, Whitsett TL, Durica SS, Comp PC, George JN, et al. The clinical validity of normal compression ultrasonography in outpatients suspected of having deep venous thrombosis. Ann Intern Med 1998;128(1):1-7. PMID: 9424975 [DOI:10.7326/0003-4819-128-1-199801010-00001]
19. Bernardi E, Camporese G, Büller HR, Siragusa S, Imberti D, Berchio A, et al. Serial 2-point ultrasonography plus D-dimer vs whole-leg color-coded Doppler ultrasonography for diagnosing suspected symptomatic deep vein thrombosis: a randomized controlled trial. JAMA 2008;300(14):1653-9. PMID: 18840838 [DOI:10.1001/jama.300.14.1653]
20. Elias A, Colombier D, Victor G, Elias M, Arnaud C, Juchet H, et al. Diagnostic performance of complete lower limb venous ultrasound in patients with clinically suspected acute pulmonary embolism. Thromb Haemost 2004;91(1):187-95. PMID: 14691585 [DOI:10.1160/TH03-05-0278]
21. Elias A, Mallard L, Elias M, Alquier C, Guidolin F, Gauthier B, et al. A single complete ultrasound investigation of the venous network for the diagnostic management of patients with a clinically suspected first episode of deep venous thrombosis of the lower limbs. Thromb Haemost 2003;89(2):221-7. PMID: 12574799 [DOI:10.1055/s-0037-1613435]
22. Schellong SM, Schwarz T, Halbritter K, Beyer J, Siegert G, Oettler W, et al. Complete compression ultrasonography of the leg veins as a single test for the diagnosis of deep vein thrombosis. Thromb Haemost 2003;89(2):228-34. PMID: 12574800 [DOI:10.1055/s-0037-1613436]
23. Stevens SM, Elliott CG, Chan KJ, Egger MJ, Ahmed KM. Withholding anticoagulation after a negative result on duplex ultrasonography for suspected symptomatic deep venous thrombosis. Ann Intern Med 2004;140(12):985-91. PMID: 15197015 [DOI:10.7326/0003-4819-140-12-200406150-00007]
24. Subramaniam RM, Heath R, Chou T, Cox K, Davis G, Swarbrick M. Deep venous thrombosis: withholding anticoagulationtherapy after negative complete lower limb US findings. Radiology 2005;237(1):348-52. PMID: 16126924 [DOI:10.1148/radiol.2371041294]
25. Sevestre MA, Labarère J, Casez P, Bressollette L, Haddouche M, Pernod G, et al. Outcomes for inpatients with normal findings on whole-leg ultrasonography: a prospective study. Am J Med 2010;123(2):158-65. PMID: 20103025 [DOI:10.1016/j.amjmed.2009.05.034]
26. Johnson SA, Stevens SM, Woller SC, Lake E, Donadini M, Cheng J, et al. Risk of deep vein thrombosis following a single negative whole-leg compression ultrasound: a systematic review and meta-analysis. JAMA 2010;303(5):438-45. PMID: 20124539 [DOI:10.1001/jama.2010.43]
27. Lensing AW, Doris CI, McGrath FP, Cogo A, Sabine MJ, Ginsberg J, et al. A comparison of compression ultrasound with color Doppler ultrasound for the diagnosis of symptomless postoperative deep vein thrombosis. Arch Intern Med 1997;157(7):765-8. PMID: 9125008 [DOI:10.1001/archinte.157.7.765]
28. Davidson BL, Elliott CG, Lensing AW. Low accuracy of color Doppler ultrasound in the detection of proximal leg vein thrombosis in asymptomatic high-risk patients. The RD Heparin Arthroplasty Group. Ann Intern Med 1992;117(9):735-8. PMID: 1416575 [DOI:10.7326/0003-4819-117-9-735]
29. Dua A, Desai SS, Nodel A, Heller JA. The impact of body mass index on lower extremity duplex ultrasonography for deep vein thrombosis diagnosis. Ann Vasc Surg 2015;29(6):1136-40. PMID: 26004960 [DOI:10.1016/j.avsg.2015.03.038]
30. Bates SM, Jaeschke R, Stevens SM, Goodacre S, Wells PS, Stevenson MD, et al. Diagnosis of DVT: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines. Chest 2012;141(2 Suppl):e351S-418S. PMID: 22315267 [DOI:10.1378/chest.141.4.1129b]
31. O'Loghlen S, Hall GJ, Zeiadin N, Milne L, Mussari B. Adventitial cystic disease of the common femoral vein-a rare mimic of deep venous thrombosis: a case report. Ann Intern Med 2016;165(1):75-6. PMID: 26955006 [DOI:10.7326/L15-0532]
32. Aguilar C, del Villar V. Combined D-dimer and clinical probability are useful for exclusion of recurrent deep venous thrombosis. Am J Hematol 2007;82(1):41-4. PMID: 16947316 [DOI:10.1002/ajh.20754]
33. Rathbun SW, Whitsett TL, Raskob GE. Negative D-dimer result to exclude recurrent deep venous thrombosis: a management trial. Ann Intern Med 2004;141(11):839-45. PMID: 15583225 [DOI:10.7326/0003-4819-141-11-200412070-00007]
34. Prandoni P, Cogo A, Bernardi E, Villalta S, Polistena P, Simioni P, et al. A simple ultrasound approach for detection of recurrent proximalvein thrombosis. Circulation 1993;88(4 Pt 1):1730-5. PMID: 8403319 [DOI:10.1161/01.CIR.88.4.1730]
35. Heijboer H, Jongbloets LM, Büller HR, Lensing AW, ten Cate JW. Clinical utility of real-time compression ultrasonography for diagnostic management of patients with recurrent venous thrombosis. Acta Radiol 1992;33(4):297-300. PMID: 1633039 [DOI:10.1080/02841859209173182]
36. Piovella F, Crippa L, Barone M, Viganò D'Angelo S, Serafini S, Galli L, et al. Normalization rates of compression ultrasonography in patients with a first episode of deep vein thrombosis of the lower limbs: association with recurrence and new thrombosis. Haematologica 2002;87(5):515-22. PMID: 12010666
37. Linkins LA, Stretton R, Probyn L, Kearon C. Interobserver agreement on ultrasound measurements of residual vein diameter, thrombus echogenicity and Doppler venous flow in patients with previous venous thrombosis. Thromb Res 2006;117(3):241-7. PMID: 16378830 [DOI:10.1016/j.thromres.2005.02.011]
38. Tan M, Velthuis SI, Westerbeek RE, VAN Rooden CJ, VAN DER Meer FJ, Huisman MV. High percentage of non-diagnostic compression ultrasonography results and the diagnosis of ipsilateral recurrent proximal deep vein thrombosis. J Thromb Haemost 2010;8(4):848-50. PMID: 20398187 [DOI:10.1111/j.1538-7836.2010.03758.x]
39. Prandoni P, Lensing AW, Bernardi E, Villalta S, Bagatella P, Girolami A, et al. The diagnostic value of compression ultrasonography in patients with suspected recurrent deep vein thrombosis. Thromb Haemost 2002;88(3):402-6. PMID: 12353067 [DOI:10.1055/s-0037-1613229]
40. Le Gal G, Kovacs MJ, Carrier M, Do K, Kahn SR, Wells PS, et al. Validation of a diagnostic approach to exclude recurrent venous thromboembolism. J Thromb Haemost 2009;7(5):752-9. PMID: 19228281 [DOI:10.1111/j.1538-7836.2009.03324.x]
41. Prandoni P, Tormene D, Dalla Valle F, Concolato A, Pesavento R. D-dimer as an adjunct to compression ultrasonography in patients with suspected recurrent deep vein thrombosis. J Thromb Haemost 2007;5(5):1076-7. PMID: 17367489 [DOI:10.1111/j.1538-7836.2007.02455.x]
42. Loud PA, Katz DS, Klippenstein DL, Shah RD, Grossman ZD. Combined CT venography and pulmonary angiography in suspected thromboembolic disease: diagnostic accuracy for deep venous evaluation. AJR Am J Roentgenol 2000;174(1):61-5. PMID: 10628455 [DOI:10.2214/ajr.174.1.1740061]
43. Duwe KM, Shiau M, Budorick NE, Austin JH, Berkmen YM. Evaluation of the lower extremity veins in patients with suspected pulmonary embolism: a retrospective comparison of helical CT venography and sonography. 2000 ARRS Executive Council Award I. American Roentgen Ray Society. AJR Am J Roentgenol 2000;175(6):1525-31. PMID: 11090368 [DOI:10.2214/ajr.175.6.1751525]
44. Garg K, Kemp JL, Wojcik D, Hoehn S, Johnston RJ, Macey LC, et al. Thromboembolic disease: comparison of combined CT pulmonary angiography and venography with bilateral leg sonography in 70 patients. AJR Am J Roentgenol 2000;175(4):997-1001. PMID: 11000152 [DOI:10.2214/ajr.175.4.1750997]
45. Garg K, Mao J. Deep venous thrombosis: spectrum of findings and pitfalls in interpretation on CT venography. AJR Am J Roentgenol 2001;177(2):319-23. PMID: 11461853 [DOI:10.2214/ajr.177.2.1770319]
46. Westerbeek RE, Van Rooden CJ, Tan M, Van Gils AP, Kok S, De Bats MJ, et al. Magnetic resonance direct thrombus imaging of the evolution of acute deep vein thrombosis of the leg. J Thromb Haemost 2008;6(7):1087-92. PMID: 18433464 [DOI:10.1111/j.1538-7836.2008.02986.x]
47. Tan M, Mol GC, van Rooden CJ, Klok FA, Westerbeek RE, Iglesias Del Sol A, et al. Magnetic resonance direct thrombus imaging differentiates acute recurrent ipsilateral deep vein thrombosis from residual thrombosis. Blood 2014;124(4):623-7. PMID: 24928859 [DOI:10.1182/blood-2014-04-566380]
48. Hull R, Hirsh J, Sackett DL, Taylor DW, Carter C, Turpie AG, et al. Clinical validity of a negative venogram in patients with clinically suspected venous thrombosis. Circulation 1981;64(3):622-5. PMID: 7261292 [DOI:10.1161/01.CIR.64.3.622]
49. Lensing AW, Büller HR, Prandoni P, Batchelor D, Molenaar AH, Cogo A, et al. Contrast venography, the gold standard for the diagnosis of deep-vein thrombosis: improvement in observer agreement. Thromb Haemost 1992;67(1):8-12. PMID: 1615489 [DOI:10.1055/s-0038-1648130]
50. Heijboer H, Cogo A, Büller HR, Prandoni P, ten Cate JW. Detection of deep vein thrombosis with impedance plethysmography and real-time compression ultrasonography in hospitalized patients. Arch Intern Med 1992;152(9):1901-3. PMID: 1520059 [DOI:10.1001/archinte.152.9.1901]
51. Kearon C, Julian JA, Newman TE, Ginsberg JS. Noninvasive diagnosis of deep venous thrombosis. McMaster Diagnostic Imaging Practice Guidelines Initiative. Ann Intern Med 1998;128(8):663-77. PMID: 9537941 [DOI:10.7326/0003-4819-128-8-199804150-00011]
52. Hull RD, Hirsh J, Carter CJ, Jay RM, Ockelford PA, Buller HR, et al. Diagnostic efficacy of impedance plethysmography for clinically suspected deep-vein thrombosis. A randomized trial. Ann Intern Med 1985;102(1):21-8. PMID: 3881068 [DOI:10.7326/0003-4819-102-1-21]
53. Couson F, Bounameaux C, Didier D, Geiser D, Meyerovitz MF, Schmitt HE, et al. Influence of variability of interpretation of contras venography for screening of postoperative deep venous thrombosis on the results of a thromboprophylactic study. Thromb Haemost 1993;70(4):573-5. PMID: 8115980 [DOI:10.1055/s-0038-1649629]
54. Couson F, Bounameaux C, Didier D, Geiser D, Meyerovitz MF, Schmitt HE, et al. Influence of variability of interpretation of contrast venography for screening of postoperative deep venous thrombosis on the results of a thromboprophylactic study. Thromb Haemost 1993;70(4):573-5. PMID: 8115980 [DOI:10.1055/s-0038-1649629]
55. Hull RD, Hirsh J, Carter CJ, Jay RM, Ockelford PA, Buller HR, et al. Diagnostic efficacy of impedance plethysmography for clinically suspected deep-vein thrombosis. A randomized trial. Ann Intern Med 1985;102(1):21-8. PMID: 3881068 [DOI:10.7326/0003-4819-102-1-21]
56. Kearon C, Julian JA, Newman TE, Ginsberg JS. Noninvasive diagnosis of deep venous thrombosis. McMaster Diagnostic Imaging Practice Guidelines Initiative. Ann Intern Med 1998;128(8):663-77. PMID: 9537941 [DOI:10.7326/0003-4819-128-8-199804150-00011]
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