Volume 2, Issue 4 (Autumn 2021)
J Vessel Circ 2021, 2(4): 209-216 |
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Hassanpour K, Abedi B, Moradi L. The Effect of a HIIT Training Course on the Expression of PGC-1α, SIRT1, and SIRT3 Genes in the Cardiac Tissue of Elderly Female Rats. J Vessel Circ 2021; 2 (4) :209-216
URL: http://jvessels.muq.ac.ir/article-1-185-en.html
URL: http://jvessels.muq.ac.ir/article-1-185-en.html
1- Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran, ava.hasanpoor2018@gmail.com
2- Department of Physical Education,Tehran North Branch, Islamic Azad University., abedi@iaumahallat. ac.ir
3- Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran., moradi.lida@gmail .com
2- Department of Physical Education,Tehran North Branch, Islamic Azad University., abedi@iaumahallat. ac.ir
3- Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran., moradi.lida@gmail .com
Abstract: (992 Views)
Background and Aim: Exercise improves the function of mitochondrial proteins and enzymes in old age. This study aimed to investigate the effect of a high-intensity interval training (HIIT) training course on the expression of PGC-1α, SIRT1, and SIRT3 genes in the cardiac tissue of elderly female rats.
Materials and Methods: In this experimental study, 14 female Sprague-Dawley rats with a mean age of 16-18 months and a weight range of 280-320 g were randomly divided into 2 groups of 7, including the control group and the HIIT training group. The experimental group performed HIIT training for 8 weeks and 5 days a week with an intensity of 85%-110% VO2max. Forty-eight hours after the last training session, rats were anesthetized by intraperitoneal injection of ketamine and xylazine, and the target tissue was immediately removed for examination. Shapiro-Wilk statistical test and one-way analysis of variance in SPSS software v. 22 analyzed the findings (P≥0.05).
Results: The results showed that the expression of PGC-1α, SIRT1, and SIRT3 genes increased in the cardiac tissue of the experimental group compared to the control group after 8 weeks of HIIT training, but this increase was not significant (P≤0.05).
Conclusion: It seems that in elderly conditions, exercise from pathways other than PGC-1α improves mitochondrial function. However, further research is needed on the effect of HIIT exercise on the expression of these genes in cardiac tissue.
Materials and Methods: In this experimental study, 14 female Sprague-Dawley rats with a mean age of 16-18 months and a weight range of 280-320 g were randomly divided into 2 groups of 7, including the control group and the HIIT training group. The experimental group performed HIIT training for 8 weeks and 5 days a week with an intensity of 85%-110% VO2max. Forty-eight hours after the last training session, rats were anesthetized by intraperitoneal injection of ketamine and xylazine, and the target tissue was immediately removed for examination. Shapiro-Wilk statistical test and one-way analysis of variance in SPSS software v. 22 analyzed the findings (P≥0.05).
Results: The results showed that the expression of PGC-1α, SIRT1, and SIRT3 genes increased in the cardiac tissue of the experimental group compared to the control group after 8 weeks of HIIT training, but this increase was not significant (P≤0.05).
Conclusion: It seems that in elderly conditions, exercise from pathways other than PGC-1α improves mitochondrial function. However, further research is needed on the effect of HIIT exercise on the expression of these genes in cardiac tissue.
Type of Study: Research |
Subject:
cardiovascular diseases
Received: 2021/11/8 | Accepted: 2021/11/23 | Published: 2021/12/31
Received: 2021/11/8 | Accepted: 2021/11/23 | Published: 2021/12/31
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